Brain imaging mechanism of electroacupuncture combined with antidepressant for mild to moderate depression: a multi-model MRI study

Not Applicable

• Conditions: depression

• Registration Number: ITMCTR2100005073
• Lead Sponsor: Beijing Hospital of Traditional Chinese Medicine, Capital Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Meet the diagnosis of mild-to-moderate depression according to the International Classification of Diseases 10th Edition (ICD-10, F32.0, F32.1);
2. Aged from 18 to 45 years, and right handed;
3. First diagnosed, have not participated in other treatment plans;
4. 24-item Hamilton Depression Scale total score<=35;
5. Signed informed consent.

Exclusion Criteria

1. Diagnosis of bipolar depression;
2. Have participated in other clinical trials in the past eight weeks;
3. Be taking antidepressants or the pharmacological effects of antidepressants have not been washed out;
4. Have received acupuncture treatment in the past two weeks;
5. Pregnant or lactating;
6. Have other serious diseases that needed to be treated;
7. Have head trauma history or other brain diseases;
8. Have suicidal plan or behavior;
9. Have any MRI contraindications.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
24-item Hamilton depression scale;

Secondary Outcome Measures

Name	Time	Method
resting-state fMRI;diffusion tensor imaging;gray matter volume and cortical thickness;Quick inventory of depressive symptomatology-self report;