Auricular electroacupuncture based on MRI brain imaging and intestinal flora in the treatment of depression and gut-brain axis mechanism and prediction of efficacy
- Conditions
- depression
Recruitment & Eligibility
- Status
- Pending
- Sex
- Male
- Target Recruitment
- Not specified
(1) Meet the ICD-10 classification criteria for moderate-to-mild (2 core symptoms + 2 accompanying symptoms), moderate (2 core symptoms + 3-4 accompanying symptoms) depression classification criteria; (2) The disease duration ranges from 2 weeks to 7 points in 2 years = HAMD-17 score = 24 points; (3) The age is between 18 and 70 years old, and the gender is not limited; (4) The education level is above junior high school, and can understand the content of the scale and cooperate with the research; (5) Volunteered to participate in this study and signed the informed consent.
(1) Patients with severe depression, or patients with severe mental illness, such as schizophrenia, mania, and those with obvious suicidal tendencies; (2) Depressive disorders caused by psychoactive substances or non-addictive substances; (3) Patients with Patients with organic brain diseases; (4) patients with serious physical diseases, such as heart disease, tumors or organic lesions of the central nervous system; (5) patients with other neurological diseases, such as epilepsy, Parkinson's disease (6) Pregnant or breastfeeding women; (7) Those with low compliance or unable to adhere to treatment for other reasons; (8) Those who are allergic to the study drug or have contraindications to fMRI scanning; (9) Those who did not sign the informed consent form.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hamilton Anxiety Scale (HAMA-14);Hamilton Depression Scale (HAMD-17);
- Secondary Outcome Measures
Name Time Method