Brain Oscillatory Signatures of Auditory Stimuli Across Different Vigilance and Sedation States
- Conditions
- SleepAnesthesia
- Interventions
- Other: Acoustic stimuli
- Registration Number
- NCT05799417
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Brief Summary
The investigators want to explore how presenting acoustic stimuli influences brain oscillatory signatures and heart rhythm- dynamics across different vigilance and sedation states.
The investigators will administer acoustic stimuli during sedation and anaesthesia while brain activity and heart activity are being recorded by electroencephalogram and electrocardiogram.
On the day following anaesthesia an optional nap/sleep period's EEG and ECG will be recorded. During this short sleep, patients will again be exposed to acoustic stimuli. The recorded EEG and ECG will be compared intra-and inter-individually to recordings from sedation and anaesthesia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 80
- Informed Consent as documented by signature
- Good general health status
- Planned ophthalmic/plastic surgery at Inselspital Berne
- Contraindications on ethical grounds
- Neurological/neurodegenerative disorder
- Hearing problems (only if patients are not able to perceive the acoustic stimuli)
- Pacemaker
- Deep brain stimulator
- Pregnancy
- Known or suspected drug or alcohol abuse
- Critical surgery procedure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Acoustic stimuli Acoustic stimuli Acoustic stimuli and comparison to within-subject baseline
- Primary Outcome Measures
Name Time Method Spindle characteristics - amplitude of spindles Continuously across anaesthesia/sedation/sleep up to 8 hours Spindle amplitude in microVolts
Spindle characteristics - frequency of spindles Continuously across anaesthesia/sedation/sleep up to 8 hours Frequency of spindles in Hz
Brain oscillatory power derived by EEG Continuously across anaesthesia/sedation/sleep up to 8 hours Brain oscillatory response to acoustic stimuli derived by power spectral density in canonical frequency bands from 0.5 up to 40 Hz.
Brain oscillatory response derived by Hilbert Amplitude Continuously across anaesthesia/sedation/sleep up to 8 hours Brain oscillatory response to acoustic stimuli derived by Hilbert-transforming EEG data and extracting Hilbert amplitude in microVolts
Spindle characteristics - number of spindles Continuously across anaesthesia/sedation/sleep up to 8 hours Number of spindles
Spindle characteristics - duration of spindles Continuously across anaesthesia/sedation/sleep up to 8 hours Duration of spindles in ms
- Secondary Outcome Measures
Name Time Method Heart rate Continuously across anaesthesia/sedation/sleep up to 8 hours Heart rate derived from echocardiogram in bpm
Instantaneous heart rate Continuously across anaesthesia/sedation/sleep up to 8 hours Instantaneous heart rate derived from echocardiogram in bpm
Heart rate variability Continuously across anaesthesia/sedation/sleep up to 8 hours Heart rate variability derived from echocardiogram in ms
Slow wave characteristics - amplitude Continuously across anaesthesia/sedation/sleep up to 8 hours Slow wave amplitude in microVolt
Slow wave characteristics - number Continuously across anaesthesia/sedation/sleep up to 8 hours Number of slow waves
Slow wave characteristics - frequency Continuously across anaesthesia/sedation/sleep up to 8 hours Frequency of slow waves in Hz
Slow wave characteristics - slope Continuously across anaesthesia/sedation/sleep up to 8 hours Slope of slow waves in microVolts/s
Number of sleep arousals Continuously across sleep up to 8 hours
Trial Locations
- Locations (1)
Inselspital
🇨ðŸ‡Bern, Switzerland