Auditory Stimulation Effect on Brain Oscillations and Sleep Dependent Learning

Not Applicable

Not yet recruiting

• Conditions: Healthy Control

• Registration Number: NCT06688526
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

The investigators are testing the impact of quiet sounds played during sleep on brain oscillations and memory.

Detailed Description

Participants will undergo two visits with a memory task and nap. During one of the visits, quiet sounds will be played timed with sleep oscillations. During the other visit, no sounds will be played. Brain oscillations and memory will be measured at each visit.

Study Timeline

• Study First Submitted: 2024-10-25
• Status Verified: 2024-11
• Study Start: 2024-11-13
• Study First Submitted QC: 2024-11-13
• Last Update Submitted: 2024-11-13
• Study First Posted: 2024-11-14
• Last Update Posted: 2024-11-14
• Primary Completion: 2025-06-30
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Adult -

Exclusion Criteria

History of neurological disease, psychiatric disease, sleep apnea or sleep disorder.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Sleep spindle rate	90 minutes	Sleep spindles are prominent thalamocortical brain oscillations seen on EEG during sleep that have been mechanistically linked to sleep-dependent memory consolidation. The sleep spindle rate over the course of the nap will be assessed using an automated spindle detector applied to the collected EEG sleep data.

Secondary Outcome Measures

Name	Time	Method
Memory consolidation	90 minutes	The motor sequence task (MST), a validated probe of memory consolidation, will be used to measure sleep-dependent memory consolidation. Participants will trained on MST before the nap opportunity and tested on MST after the nap opportunity to reliably measure memory consolidation.