The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
- Conditions
- Schizophrenia
- Interventions
- Other: Closed loop auditory stimulation during sleep
- Registration Number
- NCT06386588
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- 18-45 years old
- Fluent in English
- Able to give informed consent
Additional inclusion for Adults with schizophrenia:
- A DSM-V confirmed diagnosis of schizophrenia
- Unmedicated or maintained on a stable dose of APDs
- Ferrous metal in the body
- Currently pregnant or breastfeeding
- Motor problems that preclude finger tapping task
- IQ <85
- Other neurological disorders, including seizure disorder
- Significant hearing or vision loss
- Chronic medical conditions that affect sleep
- Unstable chronic medical condition such as asthma, diabetes, cystic fibrosis, or cardiac disease
- Diagnosed sleep disorder, except insomnia
- History of head injury resulting in prolonged loss of consciousness or other neurological sequelae
Additional Exclusion Criteria for Healthy adults:
- History of mental illness
- Current use of psychotropic medications or treatment with medications known to affect sleep or cognition
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Healthy Controls Closed loop auditory stimulation during sleep Adult participants screened to exclude a personal history of mental illness, family history of schizophrenia spectrum disorder, and psychoactive medication use. Schizophrenia Closed loop auditory stimulation during sleep Adult outpatients with a diagnosis of schizophrenia.
- Primary Outcome Measures
Name Time Method Changes in sleep physiology across 5 nights of sleep with auditory stimulation Changes in slow oscillations, sleep spindles, and slow oscillation-spindle coupled events as measured by sleep EEG headband
Changes in hippocampal microstructural integrity Approximately 30 minutes between pre- and post-task diffusion-weighted MRI scans Changes in hippocampal microstructural integrity as measured by diffusion-weighted MRI
Changes in hippocampal activation during motor sequence task (MST) Approximately 1 week between baseline and follow-up scans Changes in hippocampal activation during the MST as measured by functional MRI
Changes in functional connectivity of the hippocampus and thalamus Approximately 1 week between baseline and follow-up scans Changes in functional connectivity of the hippocampus and thalamus as measured by resting state functional connectivity MRI
- Secondary Outcome Measures
Name Time Method Greater gains in typing speed over rest breaks during MST training (micro-offline gains) Approximately 5 days between pre- and post-stimulation MST administrations MST training sessions prior to sleep consisting of typing trials separated by rest periods. We will measure typing speed before and after rest breaks.
Sleep dependent memory consolidation (SDMC) Approximately 5 days between pre- and post-stimulation MST administrations Comparison of SDMC between the Baseline MST only and MST with CLASS nights
Trial Locations
- Locations (1)
Massachusetts General Hospital
🇺🇸Charlestown, Massachusetts, United States