Effects Of Walnut-Enriched Diet On Blood Lipids And Glucose Profiles In Hyperlipidemic Subjects

Not Applicable

Completed

• Conditions: Hyperlipidemias
• Interventions: Dietary Supplement: Walnut-enriched Group

• Registration Number: NCT03680027
• Lead Sponsor: Eastern Mediterranean University

Brief Summary

Walnuts have been shown to reduce serum lipids in hyperlipidemic individuals with a well-controlled feeding trials. Current study have been determined the effects of daily walnut consumption on serum lipids, fasting glucose and insulin levels in hyperlipidemic individuals.

Detailed Description

In this, randomized controlled trial, mild to moderate hyperlipidemic subjects were randomly divided into 2 groups as walnut-enriched (n=20) and control (n=17) groups for 6 weeks. All subjects adhered to a medical nutrition therapy as low-fat and low-cholesterol diet. The walnut-enriched group was supplemented with 40 g/day of walnuts added to their diets. In order to follow nutritional status of subjects, they were visited every 15 days (in total 4 times). Anthropometric measurements of the subjects were taken and were monitored at each visit during the study. Blood samples were measured at the beginning and again at the end of the study.

Study Timeline

• Study Start: 2015-07-10
• Primary Completion: 2015-08-27
• Study Completion: 2015-09-30
• Status Verified: 2018-09
• Study First Submitted: 2018-09-19
• Study First Submitted QC: 2018-09-19
• Study First Posted: 2018-09-21
• Last Update Submitted: 2018-09-21
• Last Update Posted: 2018-09-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Hyperlipidemic patients who are not using any lipid lowering medications
• Non-smoker
• No alcohol consumption
• Individuals who are having ≤30kg/m2
• Individuals who do not have any allergy for nut consumption
• Female participants who are not pregnant or breastfeeding
• Individuals should not be in a weight loss programme
• Having not consumed regular nuts for the last 1 month,
• Except hypertension, they should not have other chronic diseases (such as diabetes, chronic renal failure)
• No intense exercise

Exclusion Criteria

• Failure to meet the criteria for inclusion criteria.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Interventional Group	Walnut-enriched Group	In 'Interventional group' participants had 6 week follow-up and during that period of time, they were asked to consume 40g/day walnut. Participants in intervention group was ensured to consume all 40g of walnut every day, during their snack times for 6 weeks.

Primary Outcome Measures

Name	Time	Method
Reduction in serum lipids and fasting glucose levels	Six weeks	In both group, participants have decreased serum total cholesterol and LDL-cholesterol.However especially walnut-enrcihed group significantly changed fasting glucose and insulin levels.