Malnutrition and Antiretroviral Timing in Children with HIV (MATCH)
Not Applicable
- Conditions
- HIV/AIDS
- Registration Number
- PACTR201609001751384
- Lead Sponsor
- Dr M Archary
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 84
Inclusion Criteria
1.Age: 1 months - 12 years
2.HIV infection as defined as a positive ELISA or Rapid HIV test in children over 18 months or a positive DNA PCR in children under 18 months.
3.ART-naïve except for antiretroviral prophylaxis given for PMTCT.
4.Severe acute malnutrition (SAM) as defined by WHO criteria: Weight-for-length 3 z-scores below the WHO growth standards median or Mid-upper arm circumference (MUAC) < 115 mm with/without peripheral edema.
5.Eligible for initiation of HAART by the SA national treatment guidelines
Exclusion Criteria
1.Enrollment in other interventional studies.
2.Lack of availability of parent/guardian willing and able to provide informed consent and adhere to study protocol.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method anthropometric response (BMIZ/WAZ/HAZ);Virological Response (VL<1000c/ml);immunological response
- Secondary Outcome Measures
Name Time Method mortality;adverse events/IRIS events