Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement

Completed

• Conditions: Myocardial Ischemia; Acute Coronary Syndrome; Myocardial Infarction; Coronary Occlusion; Coronary Thrombosis

• Registration Number: NCT00657436
• Lead Sponsor: University of Zurich

Brief Summary

The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department.

Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-03
• Study First Submitted: 2008-04-08
• Study First Submitted QC: 2008-04-08
• Study First Posted: 2008-04-14
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2012-05
• Last Update Submitted: 2012-05-30
• Last Update Posted: 2012-05-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 403

Inclusion Criteria

• All patients in the emergency department of the University Hospital Zurich with measurement of troponin during the routine diagnostic evaluation.

Exclusion Criteria

• Refusal or inability to give informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnosis of acute coronary syndrome	Emergency room and/or hospital stay

Secondary Outcome Measures

Name	Time	Method
Incidence of any acute coronary event	1 year
Morbidity from coronary artery disease	1 year
Mortality	1 year

Trial Locations

Locations (1)

Cardiology, University Hospital; 🇨🇭 Zurich, Switzerland