The Role of POLE Mutation in High Risk Endometrial Cancer.

Recruiting

• Conditions: Endometrial Neoplasms

• Registration Number: NCT07114653
• Lead Sponsor: Far Eastern Memorial Hospital

Brief Summary

The actual role of POLE mutations in high-risk endometrial cancer is undetermined. The main question it aims to answer is:

What is the prevalence of POLE mutations in high-risk endometrial cancer case? What is the impact of POLE mutations in real world high-risk endometrial cancer case?

Detailed Description

All high-risk recurrent endometrial cancer cases who were treated in a tertiary referral center will be analyzed and subjected to POLE mutation analysis. In addition, survival analysis will be used to analyze the role of POLE mutations in women with high-risk endometrial cancer. We can answers the following.

1. What is the prevalence of POLE mutations in women with high-risk endometrial cancer?

2. What is the role of POLE mutations in real world high-risk endometrial cancer?

Study Timeline

• Status Verified: 2025-08
• Study First Submitted: 2025-08-04
• Study First Submitted QC: 2025-08-04
• Last Update Submitted: 2025-08-04
• Study First Posted: 2025-08-11
• Last Update Posted: 2025-08-11
• Study Start: 2025-09-01
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

• women with high-risk for recurrent endometrial cancer

Exclusion Criteria

• Nil

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of POLE mutation in high risk endometrial cancer	2 years	The prevalence of POLE mutations in women with high-risk for recurrent endometrial cancer

Secondary Outcome Measures

Name	Time	Method
The impact of POLE on overall survival	5 years	The impact of POLE on overall survival, compared with the other TCGA groups

Trial Locations

Locations (1)

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital; 🇨🇳 Banqiao, New Taipei, Taiwan