Microbiome-Gut-Brain in Anorexia Nervosa
- Conditions
- Anorexia Nervosa
- Registration Number
- NL-OMON25454
- Lead Sponsor
- MC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
In order to be eligible to participate in this study, a subject must meet all of the following criteria: patients between 13 and 20 years of age (first-time ill with an illness duration of 1 year or less) for the first group, and between 18 and 35 years of age (>5 y ill, start in adolescence) with AN and atypical AN according to DSM-5. Controls are age-matched
Exclusion Criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study: organic brain disease, psychotic disorder, bipolar disorder, insufficient knowledge of Dutch language, an IQ lower than 80 and antibiotic use during the previous 6 weeks. Control participants are not allowed to have (a history of) an eating disorder.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Group-level differences in community structure between short-term ill adolescent AN patients, long-term ill adult AN patients and healthy controls
- Secondary Outcome Measures
Name Time Method Gut permeability and serum inflammation markers, IgG analysis and neuropsychological testin