Microbiome-Gut-Brain interaction in Anorexia Nervosa

Recruiting

• Conditions: anorexia nervosa; eating disorder; 10014067

• Registration Number: NL-OMON54859
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

Female patients between 13 and 20 years of age (first-time ill) for the first
group, and between 18 and 35 years of age (start in adolescence) with AN and
atypical AN according to DSM-5 for the second (chronic) patients.
Age-matched controls without eating disorder, BMI < 80th percentile and > 20th
percentile.

Exclusion Criteria

Organic brain disease, psychotic disorder, bipolar disorder, IQ < 80,
insufficient knowledge of Dutch language, antibiotic use during the previous 6
weeks, substance abuse, pregnancy, diabetes, or gastrointestinal diseases.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome: Differences in MI between short-term ill and long-term ill<br /><br>patients and HC, cross-sectional and longitudinally during weight restoration<br /><br>over 1 year. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes: Changes in MI composition in relation to olanzapine use,<br /><br>locomotor activity, gastrointestinal complaints, eating disorder symptoms,<br /><br>anxiety, mood, neuropsychological inefficiencies, gut permeability, serum<br /><br>inflammation markers, IgG analysis.</p><br>