Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events
- Conditions
- Hyperlipidemia
- Interventions
- Other: Placebo
- Registration Number
- NCT01968967
- Lead Sponsor
- Pfizer
- Brief Summary
This study is a multicenter, randomized study in subjects with high cholesterol receiving highly effective statins to assess the efficacy, safety and tolerability of Bococizumab (PF-04950615;RN316) to lower LDL-C.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2139
- Treated with a statin.
- Fasting LDL-C > 70 mg/dL and triglyceride <=400 mg/dL.
- High or very high risk of incurring a cardiovascular event.
- Pregnant or breastfeeding females.
- Cardiovascular or cerebrovascular event of procedures during the past 30 days.
- Congestive heart failure NYHA class IV.
- Poorly controlled hypertension.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Bococizumab (PF-04950615; RN316) Bococizumab (PF-04950615; RN316) - Placebo Placebo -
- Primary Outcome Measures
Name Time Method Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) at Week 12 Baseline, Week 12
- Secondary Outcome Measures
Name Time Method Percent Change From Baseline in Fasting Total Cholesterol (TC) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Apolipoprotein B (ApoB) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) by Triglycerides (TG) Cut-off of Less Than (<) 200 Milligram Per Deciliter (mg/dL) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) by Triglycerides Cut-off of Greater Than or Equal to (>=) 200 Milligram Per Deciliter (mg/dL) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Lipoprotein (a) (Lp[a]) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting High Density Lipoprotein Cholesterol (HDL-C) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Non High Density Lipoprotein Cholesterol (HDL-C) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) at Week 24, 52: Treatment Period Baseline, Week 24, 52 Percent Change From Baseline in Fasting Triglycerides (TG) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Apolipoprotein A-II (ApoA-II) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Absolute Change From Baseline in Fasting Non High Density Lipoprotein Cholesterol (HDL-C) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Lipoprotein (a) (Lp[a]) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting High Density Lipoprotein Cholesterol (HDL-C) at Week 12 Baseline, Week 12 Number of Participants Who Changed Concomitant Medication During Extension Period Week 58 follow-up visit to Week 110 In this outcome measure, total number of participants who changed their lipid-lowering medications or added a monoclonal antibody medication during the extension period were reported.
Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) at Week 58 Follow-up Visit, 71, 84, 97 and 110: Extension Period Baseline, Week 58 follow-up visit, 71, 84, 97, 110 Percent Change From Baseline in Fasting Apolipoprotein A-I (ApoA-I) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Absolute Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) by Triglycerides Cut-off of Less Than (<) 200 Milligram Per Deciliter (mg/dL) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Total Cholesterol (TC) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Apolipoprotein B (ApoB) at Week 12 Baseline, Week 12 Percentage of Participants Achieving Fasting Low Density Lipoprotein Cholesterol (LDL-C) Less Than or Equal to (<=) 70 Milligram Per Deciliter (mg/dL) at Week 12, 24 and 52 Week 12, 24, 52 Percentage of Participants With Anti-Drug Antibodies (ADA) and Neutralizing Antibodies (nAb): Extension Period Week 58 follow-up visit, Week 71, Week 84, Week 97, Week 110 Percentage of participants with at least 1 positive ADA titer or 1 positive nAb titer were reported. ADA titer \>=6.23 (log2) unit was considered to be ADA positive and nAb titer \>=1.58 (log2) unit was considered to be nAb positive.
Percent Change From Baseline in Fasting Very Low Density Lipoprotein Cholesterol (VLDL-C) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Absolute Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) by Triglycerides Cut-off of Greater Than or Equal to (>=) 200 Milligram Per Deciliter (mg/dL) at Week 12 Baseline, Week 12 Percentage of Participants Achieving Fasting Low Density Lipoprotein Cholesterol (LDL-C) Less Than or Equal to (<=) 100 Milligram Per Deciliter (mg/dL) at Week 12, 24 and 52 Week 12, 24, 52 Number of Participants With Adverse Events (AEs) Related to Type 1 or 3 Hypersensitivity Reactions and Injection Site Reactions Baseline up to Week 58 Type 1 hypersensitivity or allergic reactions were possible in response to any injected protein and included shortness of breath, urticaria, anaphylaxis and angioedema. Type 3 hypersensitivity reactions were similar to Type 1 hypersensitivity reactions but were likely to be delayed from the time of injection and included symptoms such as rash, urticaria, polyarthritis, myalgia's, polysynovitis, fever and if severe then included glomerulonephritis. Injection site reactions included injection site bruising, discolouration, erythema, haematoma, haemorrhage, nodule, induration, inflammation, mass, pain, paraesthesia, pruritus, swelling, vesicles, warmth, scab and rash. Participants with type 1 or type 3 hypersensitivity reactions and participants with injection site reactions were reported in this outcome measure.
Plasma Concentration of PF-04950615 at Week 12, 24 and 52 Week 12, 24, 52 Plasma concentration of PF-04950615 at Week 12, 24 and 52 was reported.
Percentage of Participants With Anti-Drug Antibodies (ADA) and Neutralizing Antibodies (nAb): Treatment Period Baseline up to Week 58 Percentage of participants with at least 1 positive ADA titer or 1 positive nAb titer were reported. ADA titer \>=6.23 (log2) unit was considered to be ADA positive and nAb titer \>=1.58 (log2) unit was considered to be nAb positive.
Absolute Change From Baseline in Ratio of Fasting Total Cholesterol (TC) to High Density Lipoprotein Cholesterol (HDL-C) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Change From Baseline in Ratio of Fasting Apolipoprotein B (ApoB) to Apolipoprotein A-I (ApoA-I) at Week 12, 24 and 52 Baseline, Week 12, 24, 52
Trial Locations
- Locations (247)
San Marcus Research Clinic, Inc.
🇺🇸Miami, Florida, United States
Clinical Research of Miami
🇺🇸Miami, Florida, United States
Finlay Medical Research
🇺🇸Miami, Florida, United States
International Research Associates, LLC
🇺🇸Miami, Florida, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Texas Center for Drug Development, Inc.
🇺🇸Houston, Texas, United States
Pioneer Research Solutions, Inc.
🇺🇸Houston, Texas, United States
The Lindner Center for Research and Education at The Christ Hospital
🇺🇸Cincinnati, Ohio, United States
Clinical Research of South Nevada
🇺🇸Las Vegas, Nevada, United States
Metabolic and Atherosclerosis Research Center
🇺🇸Cincinnati, Ohio, United States
Sentral Clinical Research Services - Admin Only
🇺🇸Cincinnati, Ohio, United States
North Georgia Clinical Research
🇺🇸Woodstock, Georgia, United States
Manassas Clinical Research Center
🇺🇸Manassas, Virginia, United States
Amherst Family Practice, P.C.
🇺🇸Winchester, Virginia, United States
Bandera Family Health Care, LLC
🇺🇸San Antonio, Texas, United States
Ernest L. Hendrix, MD, PC
🇺🇸Athens, Alabama, United States
North Alabama Research Center, LLC
🇺🇸Athens, Alabama, United States
Heart Center Research, Llc
🇺🇸Huntsville, Alabama, United States
Care Clinical Research Corporation
🇺🇸Banning, California, United States
Advanced Arizona Clinical Research
🇺🇸Tucson, Arizona, United States
Med Center
🇺🇸Carmichael, California, United States
Med Investigations
🇺🇸Fair Oaks, California, United States
California Heart Specialists
🇺🇸Huntington Beach, California, United States
Alia Clinical Research, Inc.
🇺🇸Huntington Park, California, United States
Downtown L.A. Research Center, Inc.
🇺🇸Los Angeles, California, United States
California Medical Research Associates Inc.
🇺🇸Northridge, California, United States
Richard S. Cherlin, M.D.
🇺🇸Los Gatos, California, United States
Arch Health Partners Clinical Research Department
🇺🇸Poway, California, United States
Empire Clinical Research
🇺🇸Upland, California, United States
Orange County Research Center
🇺🇸Tustin, California, United States
Alta California Medical Group
🇺🇸Simi Valley, California, United States
Diablo Clinical Research, Inc.
🇺🇸Walnut Creek, California, United States
Infosphere Clinical Research, INC
🇺🇸West Hills, California, United States
YNHH, Heart and Vascular
🇺🇸North Haven, Connecticut, United States
ACRC-Cardiology
🇺🇸Atlantis, Florida, United States
The Research Center, Inc.
🇺🇸Hialeah, Florida, United States
AGA Clinical Trials
🇺🇸Hialeah, Florida, United States
St. Vincent's Cardiology
🇺🇸Jacksonville, Florida, United States
Kendall South Medical Center
🇺🇸Miami, Florida, United States
A&R Research Group, LLC
🇺🇸Pembroke Pines, Florida, United States
DBC Research
🇺🇸Pembroke Pines, Florida, United States
Atlanta Diabetes Associates
🇺🇸Atlanta, Georgia, United States
Metabolic Research Institute Incorporated
🇺🇸West Palm Beach, Florida, United States
North Georgia Internal Medicine
🇺🇸Woodstock, Georgia, United States
Atlanta Center for Clinical Research / Internal Medicine
🇺🇸Roswell, Georgia, United States
Northwest Clinical Trials, Inc.
🇺🇸Boise, Idaho, United States
Investigators Research Group, LLC
🇺🇸Brownsburg, Indiana, United States
Buynak Clinical Research, P.C.
🇺🇸Valparaiso, Indiana, United States
American Health Network, LLC
🇺🇸Indianapolis, Indiana, United States
Midwest Institute for Clinical Research
🇺🇸Indianapolis, Indiana, United States
West Broadway Clinic
🇺🇸Council Bluffs, Iowa, United States
The University of Iowa - College of Public Health - Preventive Intervention Center
🇺🇸Iowa City, Iowa, United States
Omega Clinical Research
🇺🇸Metairie, Louisiana, United States
New Orleans Center for Clinical Research
🇺🇸Knoxville, Tennessee, United States
Southern Maine Health Care
🇺🇸Biddeford, Maine, United States
Columbia Medical Practice
🇺🇸Columbia, Maryland, United States
Oakland Medical Research Center
🇺🇸Troy, Michigan, United States
Mercy Health Research
🇺🇸Washington, Missouri, United States
Om Medical
🇺🇸Las Vegas, Nevada, United States
Drug Trials Brooklyn
🇺🇸Brooklyn, New York, United States
Cardio Metabolic Institute
🇺🇸Somerset, New Jersey, United States
Drug Trials America
🇺🇸Hartsdale, New York, United States
Albany Medical College, Division of Community Endocrinology
🇺🇸Albany, New York, United States
Sensenbrenner Primary Care
🇺🇸Charlotte, North Carolina, United States
SJH Cardiology Associates
🇺🇸Liverpool, New York, United States
Mid Hudson Medical Research, PLLC
🇺🇸New Windsor, New York, United States
PharmQuest
🇺🇸Greensboro, North Carolina, United States
Crossroads Clinical Research, Inc.
🇺🇸Mooresville, North Carolina, United States
PMG Research of Salisbury, LLC
🇺🇸Salisbury, North Carolina, United States
PMG Research of Wilmington, LLC
🇺🇸Wilmington, North Carolina, United States
Community Health Care, Inc.
🇺🇸Canal Fulton, Ohio, United States
Sterling Research Group, Ltd.
🇺🇸Cincinnati, Ohio, United States
Radiant Research, Inc
🇺🇸Akron, Ohio, United States
Clinical Research Institute of Southern Oregon, PC
🇺🇸Medford, Oregon, United States
Brandywine Clinical Research
🇺🇸Downingtown, Pennsylvania, United States
LION Research
🇺🇸Norman, Oklahoma, United States
Sentral Clinical Research Services
🇺🇸Cincinnati, Ohio, United States
Altoona Center for Clinical Research
🇺🇸Duncansville, Pennsylvania, United States
Liberty Family Practice
🇺🇸Erie, Pennsylvania, United States
Suburban Research Associates
🇺🇸Media, Pennsylvania, United States
Detweiler Family Medicine and Associates, PC
🇺🇸Lansdale, Pennsylvania, United States
Allegheny Endocrinology Associates
🇺🇸Pittsburgh, Pennsylvania, United States
Guthrie Medical Group, PC
🇺🇸Sayre, Pennsylvania, United States
Upstate Pharmaceutical Research
🇺🇸Greenville, South Carolina, United States
Warminster Medical Associates, P.C.
🇺🇸Warminster, Pennsylvania, United States
KRK Medical Research
🇺🇸Arlington, Texas, United States
North Texas Healthcare System, Dallas VAMC
🇺🇸Dallas, Texas, United States
University of North Texas Health Science Center at Fort Worth
🇺🇸Fort Worth, Texas, United States
Research Institute of Dallas
🇺🇸Dallas, Texas, United States
lnvestigational Drug Services (IDA)
🇺🇸Houston, Texas, United States
Sun Research Institute
🇺🇸San Antonio, Texas, United States
Northwest Houston Cardiology
🇺🇸Houston, Texas, United States
Hill Country Medical Associates
🇺🇸New Braunfels, Texas, United States
Advanced Clinical Research Associates
🇺🇸Plano, Texas, United States
Northwest Heart Center
🇺🇸Tomball, Texas, United States
Rainier Clinical Research Center
🇺🇸Renton, Washington, United States
Selma Medical Associates
🇺🇸Winchester, Virginia, United States
Zain Research LLC
🇺🇸Richland, Washington, United States
London Health Sciences Centre
🇨🇦London, Ontario, Canada
Vizel Cardiac Research, Saul Vizel Professional Medicine Corporation
🇨🇦Cambridge, Ontario, Canada
The Office of Dr. Allen Greenspoon
🇨🇦Hamilton, Ontario, Canada
Stroke Prevention & Atherosclerosis Research Centre (SPARC)
🇨🇦London, Ontario, Canada
St. Michael's Hospital Health Centre
🇨🇦Toronto, Ontario, Canada
Omnispec Clinical Research Inc.
🇨🇦Mirabel, Quebec, Canada
Rhodin Recherche Clinique
🇨🇦Drummondville, Quebec, Canada
BIOMELAB Ltda.
🇨🇴Barranquilla, Atlantico, Colombia
Fundacion del Caribe para la Investigacion Biomedica-Fundacion Bios
🇨🇴Barranquilla, Atlantico, Colombia
IPS Centro Cientifico Asistencial Jose Luis Accini S.A.S.
🇨🇴Barranquilla, Atlantico, Colombia
Centro de Diagnostico Cardiologico LTDA.
🇨🇴Cartagena, Bolivar, Colombia
Asociacion IPS Medicos InterniStas de Caldas
🇨🇴Manizales, Caldas, Colombia
Dexa Diab Servicios Medicos Ltda. IPS
🇨🇴Bogota, Cundinamarca, Colombia
Fundacion Cardiomet - CEQUIN
🇨🇴Armenia, Quindio, Colombia
Nouvelles Cliniques Nantaises
🇫🇷Nantes, France
CHU La Miletrie
🇫🇷Poitiers, France
Hopital Guy Chatiliez
🇫🇷Tourcoing, France
Hopital Guy Chatillez
🇫🇷Tourcoing, France
Magyar Imre Korhaz, Belgyogyaszati Szakrendeles
🇭🇺Ajka, Hungary
Bajai Szent Rokus Korhaz
🇭🇺Baja, Hungary
SYNEXUS Magyarorszag Kft.
🇭🇺Budapest, Hungary
DRC Kft.
🇭🇺Balatonfured, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz, es Egyetemi Oktatokorhaz
🇭🇺Miskolc, Hungary
Synexus Magyarorzag Kft.
🇭🇺Budapest, Hungary
Zala Megyei Korhaz
🇭🇺Zalaegerszeg, Hungary
PI Kaunas Silainiai Outpatient Clinic
🇱🇹Kaunas, Lithuania
Private Clinic Elite Medicale
🇱🇹Kaunas, Lithuania
Vilnius University Hospital Santariskiu Klinikos
🇱🇹Vilnius, Lithuania
Hospital General de Naucalpan "Dr. Maximiliano Ruiz Castaneda" (Emergencies)
🇲🇽Naucalpan, Estado DE Mexico, Mexico
Administradora de Clinicas S.A. de C.V. Hospital Inovamed Cuernavaca
🇲🇽Cuernavaca, Morelos, Mexico
Hospital Angeles Centro Medico del Potosi (Emergencies)
🇲🇽San Luis Potosi, Mexico
Centro de Investigacion Cardiometabolica de Aguascalientes SA de CV
🇲🇽Aguascalientes, Mexico
Centrul Medical de Diagnostic si Tratament Ambulator Neomed, Medicina Interna
🇷🇴Brasov, Romania
Saint-Petersburg State Budgetary Institution of Healthcare Municipal hospital # 40 of the Kurortnyi
🇷🇺Saint-Petersburg, Russian Federation
Centro Salud Petrer I
🇪🇸Petrer, Alicante, Spain
Hospital Universitario Sant Joan de Reus
🇪🇸Reus, Tarragona, Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital Universitario Quiron Madrid
🇪🇸Pozuelo de Alarcon, Madrid, Spain
Hospital Universitario La Paz; Unidad Metabolico-Vascular
🇪🇸Madrid, Spain
Hospital Clinico Universitario Miguel Servet; Medicina Interna
🇪🇸Zaragoza, Spain
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Synexus Thames Valley Clinical Research Centre
🇬🇧Reading, Berkshire, United Kingdom
Synexus Lancashire Clinical Research Centre
🇬🇧Chorley, Lancashire, United Kingdom
Synexus Wales Clinical Research Centre
🇬🇧Cardiff, Llanishen, United Kingdom
Synexus North East Clinical Research Centre
🇬🇧Hexham, Northumberland, United Kingdom
Synexus Merseyside Clinical Research Centre
🇬🇧Liverpool, Merseyside, United Kingdom
Northmed Clinical Research Ltd, Randalstown Health Centre
🇬🇧Antrim, Northern Ireland, United Kingdom
Synexus Midlands Clinical Research Centre
🇬🇧Birmingham, WEST Midlands, United Kingdom
Ninewells Hospital & Medical School
🇬🇧Dundee, United Kingdom
Midwest Heart and Vascular Specialists
🇺🇸Overland Park, Kansas, United States
Clinical Research Advantage, Inc./Colorado Springs Health Partners, SW
🇺🇸Colorado Springs, Colorado, United States
HealthEast St. Joseph's Hospital Pharmacy
🇺🇸Saint Paul, Minnesota, United States
Clinicos, LLC
🇺🇸Colorado Springs, Colorado, United States
Radiant Research, Inc.
🇺🇸Edina, Minnesota, United States
Hospital Universitario La Ribera
🇪🇸Alzira, Valencia, Spain
HealthEast Medical Research Institute
🇺🇸Saint Paul, Minnesota, United States
Radiant Research Incorporated
🇺🇸Chandler, Arizona, United States
Discovery Clinical Services Ltd.
🇨🇦Victoria, British Columbia, Canada
St. Johns Center for Clinical Research
🇺🇸Ponte Vedra, Florida, United States
Montreal Heart Institute
🇨🇦Montreal, Quebec, Canada
Michigan Heart and Vascular Specialists
🇺🇸Petoskey, Michigan, United States
Westside Family Medical Center, Pc
🇺🇸Kalamazoo, Michigan, United States
Solaris Clinical Research
🇺🇸Meridian, Idaho, United States
Medical Research Center
🇺🇸Miami, Florida, United States
East Coast Institute for Research, LLC at Baker-Gilmour Cardiovascular Institute, PA
🇺🇸Jacksonville, Florida, United States
IHA Chelsea Family & Internal Medicine
🇺🇸Chelsea, Michigan, United States
Avail Clinical Research, LLC
🇺🇸DeLand, Florida, United States
Homestead Medical Research Inc.
🇺🇸Homestead, Florida, United States
Arizona Center For Internal Medicine
🇺🇸Mesa, Arizona, United States
Rutgers Biomedical and Health Sciences- Robert Wood Johnson Medical School
🇺🇸New Brunswick, New Jersey, United States
Holland Center for Family Health
🇺🇸Peoria, Arizona, United States
MD Medical Research
🇺🇸Oxon Hill, Maryland, United States
Oviedo Medical Research, LLC
🇺🇸Oviedo, Florida, United States
Invesclinic, LLC
🇺🇸Fort Lauderdale, Florida, United States
Advanced Research Associates
🇺🇸Glendale, Arizona, United States
South Miami Clinical Research Center, LLC
🇺🇸South Miami, Florida, United States
Desert Sun Clinical Research, LLC
🇺🇸Tucson, Arizona, United States
Fleming Island Center for Clinical Research
🇺🇸Fleming Island, Florida, United States
Morton Plant Mease Health Care, Inc. Cardiovascular Research
🇺🇸Clearwater, Florida, United States
LMC Research Inc. d.b.a. Manna Research Inc.
🇨🇦Levis, Quebec, Canada
Westside Center for Clinical Research
🇺🇸Jacksonville, Florida, United States
Nature Coast Clinical Research
🇺🇸Inverness, Florida, United States
Clinical Research of Central Florida
🇺🇸Winter Haven, Florida, United States
Dolphin Medical Research
🇺🇸Virginia Gardens, Florida, United States
Centro de Atención e Investigación Cardiovascular del Potosí S.C.
🇲🇽San Luis Potosí, SAN LUIS Potosi, Mexico
Spitalul Clinic Judetean de Urgenta Craiova, Cardiologie
🇷🇴Craiova, Dolj, Romania
Municipal Institution of Healthcare "City Clinical Hospital 12
🇷🇺Saratov, Russian Federation
Volunteer Research Group
🇺🇸Knoxville, Tennessee, United States
QUEST Research Institute
🇺🇸Farmington Hills, Michigan, United States
DIEX Research Sherbrooke Inc.
🇨🇦Sherbrooke, Quebec, Canada
London Road Diagnostic Clinic and Medical Centre
🇨🇦Sarnia, Ontario, Canada
Cardiovascular Research of Knoxville
🇺🇸Knoxville, Tennessee, United States
Pecsi Tudomanyegyetem
🇭🇺Pecs, Hungary
Centro de Investigaciones Clinicas S.A.S
🇨🇴Cali, Valle DEL Cauca, Colombia
Premier Research
🇺🇸Trenton, New Jersey, United States
Fundacion Centro de Investigaciones Biomedicas RIESCARD
🇨🇴Espinal, Tolima, Colombia
Rodrigo Botero S.A.S
🇨🇴Medellin, Antioquia, Colombia
CHU de Toulouse - Hopital Rangueil
🇫🇷Toulouse cedex 9, France
Newmarket Cardiology Research Group
🇨🇦Newmarket, Ontario, Canada
Centro de Medicina del Ejercicio y Rehabilitacion Cardiaca S.A. CEMDE S.A.
🇨🇴Medellin, Antioquia, Colombia
Instituto de Investigacion Endocrinologia y Prevencion Metabolica ENDOCARE LTDA
🇨🇴Bogota, Cundinamarca, Colombia
Fundacion Cardiovascular De Colombia
🇨🇴Floridablanca, Santander, Colombia
Spitalul Universitar de Urgenta Militar Central, Dr. Carol Davila"
🇷🇴Bucuresti, Romania
Elit Medical SRL
🇷🇴Ploiesti, Romania
Saint-Petersburg State Budgetary Institution of Healthcare "Municipal Hospital #15"
🇷🇺Saint-Petersburg, Russian Federation
Cardinal Tien Hospital
🇨🇳New Taipei City, Taiwan
Instituto de Diabetes, Obesidad y Nutricion S.C.
🇲🇽Cuernavaca, Morelos, Mexico
Centro Hospitalario Mac, S.A. De C.V. (Emergencies)
🇲🇽Aguascalientes, Mexico
China Medical University Hospital
🇨🇳Taichung, Taiwan
Lausmed Kft.
🇭🇺Baja, Hungary
Pharma 4 Trial Kft.
🇭🇺Gyongyos, Hungary
TaNaMed Kft.
🇭🇺Mosonmagyarovar, Hungary
PI Klaipeda Seamen Hospital
🇱🇹Klaipeda, Lithuania
Clinicos Asociados BOCM, S.C.
🇲🇽Mexico, Distrito Federal, Mexico
Instituto Jalisciense de Investigacion en Diabetes y Obesidad, S.C.
🇲🇽Guadalajara, Jalisco, Mexico
Centenario Hospital Miguel Hidalgo
🇲🇽Aguascalientes, Mexico
Centrul Medical Unirea, Diabet Nutritie si Boli Metabolice
🇷🇴Cluj-Napoca, Romania
Federal State Budgetary Institution "Research Institute of Complex problems of Cardio-vascular
🇷🇺Kemerovo, Russian Federation
LLC "Institute of medical research"
🇷🇺St. Petersburg, Russian Federation
Hospital Universitario de Bellvitge
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
The Crouch Oak Family Practice
🇬🇧Addlestone, Surrey, United Kingdom
Synexus North East Clinical Research Centre-Hexham General Hospital
🇬🇧Hexham, Northumberland, United Kingdom
The Bradford on Avon & Melksham Health Partnership
🇬🇧Bradford on Avon, Wiltshire, United Kingdom
The Kirklin Clinic
🇺🇸Birmingham, Alabama, United States
Alabama Internal Medicine, P.C.
🇺🇸Birmingham, Alabama, United States
Drug Shipment and Study Conducted at Address: University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Elite Clinical Studies, LLC
🇺🇸Phoenix, Arizona, United States
Phoenix Clinical
🇺🇸Phoenix, Arizona, United States
Synexus Manchester Clinical Research Centre
🇬🇧Manchester, Greater Manchester, United Kingdom
Synexus Scotland Clinical Research Centre
🇬🇧Glasgow, Lanarkshire, United Kingdom
Hospital Clinico Universitario Santiago de Compostela
🇪🇸Santiago de Compostela, Galicia, Spain
Clinical Trials Research
🇺🇸Sacramento, California, United States
Northern California Research
🇺🇸Sacramento, California, United States
Florida Institute For Clinical Research, LLC
🇺🇸Orlando, Florida, United States
KCUMB Center for Community and Clinical Research
🇺🇸Kansas City, Missouri, United States
PMG Research of Winston-Salem
🇺🇸Winston-Salem, North Carolina, United States
Coastal Cardiology
🇺🇸Charleston, South Carolina, United States
Florida Research Network, LLC
🇺🇸Gainesville, Florida, United States
East-West Medical Research Institute
🇺🇸Honolulu, Hawaii, United States
National Clinical Research-Richmond, Inc.
🇺🇸Richmond, Virginia, United States
East Coast Institute for Research, LLC at Jacksonville Cardiovascular Center
🇺🇸Jacksonville, Florida, United States
East Coast Institute for Research, LLC at Northeast Florida Cardiology Clinic
🇺🇸Jacksonville, Florida, United States
East Coast Institute for Research, LLC at Northeast Florida Endocrine & Diabetes Associates
🇺🇸Jacksonville, Florida, United States
Palmetto Clinical Research
🇺🇸Summerville, South Carolina, United States
FSAEI of Higher Education "People's Friendship University of Russia",
🇷🇺Moscow, Russian Federation
Southern Health & Social Care Trust, Craigavon Area Hospital
🇬🇧Portadown, Northern Ireland, United Kingdom
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Radiant Research
🇺🇸Murray, Utah, United States