To study if a smaller dose of propofol given prior to the actual dose will be able to reduce its total dose required.

Not yet recruiting

Conditions: Malignant neoplasms of thyroid and other endocrine glands, (2) ICD-10 Condition: H65-H75||Diseases of middle ear and mastoid, (3) ICD-10 Condition: K35-K38||Diseases of appendix, (4) ICD-10 Condition: K80-K87||Disorders of gallbladder, biliary tract and pancreas, (5) ICD-10 Condition: K40-K46||Hernia,

Registration Number: CTRI/2020/06/025742

Lead Sponsor: REEHANA JABARULLA

Brief Summary: induction of anesthesia is a crucial event in general anesthesia. Propofol is one of the commonly used intravenous induction anesthetic today, on account of its smoother and rapid onset, rapid emergence with remarkable orientation of patients and minimal side effects.

in addition, one of the major benefits is the prevention of post operative nausea and vomiting.

but on the other hand, as an induction agent propofol can have hemodynamic effects which are significant.

in this study , we are applying priming principle, a sub anesthetic dose administration of propofol, with the aim of reducing the induction dose requirement and hence better hemodynamic stability..

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

ASA 1 and 2.

Exclusion Criteria

H/O allergy to egg, opioids Alcoholics H/O intake of CNS depressants ASA 3 and 4 Haemodynamic instability BMI > 35 Anticipated difficult intubation Pregnancy and lactating mothers.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To Study the Effect of Priming Principle on the Induction dose requirement of Propofol.	1 year

Secondary Outcome Measures

Name	Time	Method
To Compare the Hemodynamics between the group in which Priming Principle was applied and the group in which No priming was applied.

Trial Locations

Locations (1): PSGIMSR
🇮🇳
Coimbatore, TAMIL NADU, India
PSGIMSR
🇮🇳Coimbatore, TAMIL NADU, India
REEHANA JABARULLA
Principal investigator
8610578738
jr2205@gmail.com