Effect of Olive Oil Consumption on Cardiovascular Biomarkers

Not Applicable

• Conditions: Cardiovascular Risk Factor
• Interventions: Dietary Supplement: Olive oil; Dietary Supplement: Butter

• Registration Number: NCT04187638
• Lead Sponsor: Northumbria University

Brief Summary

The main aim of this study is to examine the effect of olive oil consumption on several cardiovascular risk markers between Caucasians and Asian ethnicity. The primary assessments: endothelial function's biomarkers: cell and vascular adhesion molecules (ICAMs and VCAMs) and nitric oxide (NO). The secondary assessments: Lipid profile.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-31
• Study First Submitted: 2019-11-28
• Study First Submitted QC: 2019-12-04
• Study First Posted: 2019-12-05
• Primary Completion: 2019-12-31
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-16
• Last Update Posted: 2020-03-17
• Study Completion: 2020-08-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

Male

Orient Asians (including Chinese, Japanese, Korean, and Malaysia Chinese) and Caucasians

Age 18-70 years

Self-reported in good general health

Exclusion Criteria

Female

Age older than 70 years or younger than 18 years

Diagnosed and/or are taking medications for hypertension (>140/90mmHg)

Diabetes

High blood cholesterol

Heart problems (e.g. arrhythmia, high-grade stenosis of the carotid artery or carotid sinus syndrome)

Allergy to olive oil or olive oil products

Lactose intolerance

Taking omega-3 supplements in fish oil and vitamins supplements in the last six months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Olive oil	Butter	Participants will receive 30ml/day of olive oil for two weeks
Butter	Butter	Participants will receive 30g/day of butter also for two weeks.
Olive oil	Olive oil	Participants will receive 30ml/day of olive oil for two weeks
Butter	Olive oil	Participants will receive 30g/day of butter also for two weeks.

Primary Outcome Measures

Name	Time	Method
changes in ambulatory blood pressure	Baseline and 2 weeks

Secondary Outcome Measures

Name	Time	Method
Changes in vascular cell adhesion molecule 1	Baseline and 2 weeks	Plasma levels of vascular cell adhesion molecule 1 measured
Changes in plasma total cholesterol	Baseline and 2 weeks	Plasma total cholesterol vascular cell adhesion molecule 1
Changes in Intercellular Adhesion Molecule 1	Baseline and 2 weeks	Plasma levels of Intercellular Adhesion Molecule 1 measured
Changes in C-reactive protein	Baseline and 2 weeks	Plasma levels of CRP measured

Trial Locations

Locations (1)

Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University; 🇬🇧 Newcastle upon Tyne, United Kingdom