Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults

Not Applicable

Completed

• Conditions: Ischemic Preconditioning
• Interventions: Device: Remote ischemic conditioning equipment; Procedure: Intravenous blood collection; Procedure: dCA measurement

• Registration Number: NCT02965547
• Lead Sponsor: Yi Yang

Brief Summary

The purpose of this study is to determine the impact of remote ischemic preconditioning on dynamic cerebral autoregulation and related hematology indexes in healthy adults.

Detailed Description

Remote ischemic preconditioning(RIPC) is the phenomenon whereby brief cycles of ischemia and reperfusion, applied to a distant organ, provide protection to the target organ. Dynamic cerebral autoregulation(dCA), a mechanism to maintain the cerebral blood flow, has been proved to be critical for the occurrence,development and prognosis of ischemic neurovascular disease. In this study, we hypothesis that RIPC provides neuro-protection by means of improving dCA.

Study Timeline

• Study First Submitted: 2016-11-14
• Study First Submitted QC: 2016-11-14
• Study First Posted: 2016-11-16
• Status Verified: 2016-12
• Study Start: 2017-01-01
• Primary Completion: 2017-05
• Study Completion: 2017-07-25
• Last Update Submitted: 2021-08-18
• Last Update Posted: 2021-08-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Age from 18 to 70,both genders
• Willing to participate in follow-up visits

Exclusion Criteria

• current or having a history of chronic physical diseases or mental diseases
• suffering from infectious diseases in late one month
• pregnant and lactating women；
• smoking or drinking；
• inability to cooperate sufficiently to complete the dCA examination

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
RIPC Group	Remote ischemic conditioning equipment	RIPC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take RIPC intervention, blood collection and 7 dCA measurements.
RIPC Group	dCA measurement	RIPC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take RIPC intervention, blood collection and 7 dCA measurements.
RIPC Group	Intravenous blood collection	RIPC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take RIPC intervention, blood collection and 7 dCA measurements.

Primary Outcome Measures

Name	Time	Method
phase difference(PD) in degree	2 days	A dynamic cerebral auto-regulation parameter derived from transfer function analysis.Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the autoregulatory parameters.
the rate of recovery of cerebral blood flow velocity	2 days
gain in cm/s/mmHg	2 days

Secondary Outcome Measures

Name	Time	Method
pulsatility index (PI) changes from supine to upright position	2 days
resistance index (RI) changes from supine to upright position	2 days
mean middle cerebral artery blood flow velocity (mCBFV) changes from supine to upright position	2 days

Trial Locations

Locations (1)

First Hospital of Jilin University; 🇨🇳 Changchun, Jilin, China