Physical Therapy for Liver Cirrhosis

Not Applicable

Completed

• Conditions: Liver Cirrhosis, Biliary

• Registration Number: NCT04629456
• Lead Sponsor: Cairo University

Brief Summary

Patients with liver cirrhosis have severe physical deconditioning. Aim: To compare between the effect of neuromuscular electric stimulation(NMES) and exercises (EX)on treatment of patients with liver cirrhosis.

Detailed Description

70 patients have been chosen from department of internal medicine, Cairo university hospitals, Egypt. 5 patients refused to participate .65 patients divided randomly into 2 groups. All the procedures were explained to patients.2 patients refused to sign informed consent and excluded from the study. 31 patients in group1 and 32 patients in group2. 1patients dropped in group1 and excluded from the study and two patients didn't continued the programmed treatment in group 2 and their data removed.

Thirty patients in each group signed an informed consent and complete the treatment program.

Study Timeline

• Study Start: 2020-01-07
• Primary Completion: 2020-05-12
• Study Completion: 2020-06-05
• Status Verified: 2020-11
• Study First Submitted: 2020-11-10
• Study First Submitted QC: 2020-11-10
• Last Update Submitted: 2020-11-10
• Study First Posted: 2020-11-16
• Last Update Posted: 2020-11-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Positive for anti-HCV.
• Not under antiviral therapy at entry.
• Positive for chronic hepatitis or compensated cirrhosis.
• Negative for hepatitis B surface (HBs) antigen.
• Free of co-infection with HIV.
• Not pregnant.
• Systolic blood pressure of less than 180 mmHg or diastolic blood pressure of less than 110 mmHg.
• (viii)No ischemic heart disease or severe arrhythmia

Exclusion Criteria

• Significant cardiac disease (ejection fraction <60% or history of coronary artery disease).
• Chronic renal failure on dialysis.
• Hemoglobin <11.0 g/L.
• Human immunodeficiency virus infection.
• Hepatocellular carcinoma.
• Active non-hepatocellular carcinoma related malignancy.
• Myopathy.
• Any physical impairment or orthopedic abnormality preventing EX, or post-liver transplantation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Sitting standing test	12 week	number of cycle /30 seconds
Balance	12 weeks	Seconds
Chronic liver diseases questionnaire (CLDQ)	12 week	score
SF-36	12 week	Score
Time up and go test	12 weeks	number of cycle / minute
6 Minutes walk distance	12 weeks	distance walked in 6 minutes
2 Minutes steps test	12 weeks	number of steps in 2 minutes.

Trial Locations

Locations (1)

Manal K. youssef; 🇪🇬 Cairo, Egypt