The Effect of Structured Lifestyle Modification and Yoga Practice on Metabolic Processes Associated With Cardiovascular Disease
- Conditions
- Coronary Artery Disease
- Interventions
- Behavioral: Chair Yoga
- Registration Number
- NCT05250310
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Brief Summary
The aim of the prospective randomized single center study is to evaluate the effect of a short-term (16 weeks) yoga program on micro RNA (miRNA) expression and cardiovascular disease (CVD) risk factors in patients with CVD.
- Detailed Description
Cardiovascular disease (CVD) and metabolic syndrome (MetS) are major public health problems in the USA and worldwide. Yoga has been proven effective in numerous studies to improve cardiovascular risk factors, with a reduction in the risk of heart attacks and strokes. MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism by playing a crucial role in cholesterol and lipid metabolism, fatty acid metabolism, insulin and glucose homeostasis. Yoga has been shown to induce a dynamic shift in miRNAs and reset their target genes expression associated with metabolites and pathways connected to CVD and MetS to a normal physiological state. 120 subjects will be included in the study. After recruitment, subjects will be randomized to one of two groups: Yoga (n=60) or Control (n=60) group. Patients randomized to Yoga, will practice yoga poses in a chair for 30 min at least 3 days a week by watching video instruction for 16 weeks. Control group patients will follow standard of care (SOC) treatment. At the enrollment day and at the 16-weeks follow-up visit, 15ml of blood will be collected from all participants for miRNAs expression profile.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
Not provided
- Physical/psychological limitation or unwillingness to practice yoga,
- Congestive heart failure, known arrthymias or prior Automated Implantable Cardioverter-Defibrillator /pacemaker or any metallic implants,
- Rheumatological/immunological diseases,
- History of transplant,
- Moderate to severe chronic obstructive pulmonary disease, debilitating or severe systemic Illness,
- Subjects who are pregnant or postpartum less than 6 months,
- Liver disease or alcohol use of more than 7 alcoholic drinks/week in women and more than 14 drinks/week in men
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Yoga Chair Yoga Patients randomized to Yoga arm will practice chair yoga for 30 minutes at least three days a week for 16 weeks
- Primary Outcome Measures
Name Time Method micro RNA expression End of study, at 22 months
- Secondary Outcome Measures
Name Time Method Body weight End of study, at 22 months Body weight, kg
Blood pressure End of study, at 22 months blood pressure
Waist circumference End of study, at 22 months Waist circumference, inches
Trial Locations
- Locations (1)
Mount Sinai Hospital
🇺🇸New York, New York, United States