Ayahuasca and Esketamine for Major Depression

Not Applicable

Completed

• Conditions: Major Depression Severe
• Interventions: Drug: Ayahuasca; Drug: Esketamine

• Registration Number: NCT07212946
• Lead Sponsor: University of Sao Paulo

Brief Summary

Double-blind, randomized trial comparing 4 weekly doses of oral ayahuasca and esketamine in patients with major depression.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-30
• Primary Completion: 2024-10-30
• Status Verified: 2025-10
• Study Completion: 2025-10-01
• Study First Submitted: 2025-10-01
• Study First Submitted QC: 2025-10-01
• Last Update Submitted: 2025-10-01
• Study First Posted: 2025-10-08
• Last Update Posted: 2025-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

major depressive disorder without comorbidities -

Exclusion Criteria

psychiatric and other medical comorbidities

-

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ayahuasca	Ayahuasca	-
ayahuasca	Esketamine	-
esketamine	Ayahuasca	-
esketamine	Esketamine	-

Primary Outcome Measures

Name	Time	Method
Beck Depression Inventory	49 days

Trial Locations

Locations (1)

Hospital das Clínicas da FMRP-USP; 🇧🇷 Ribeirão Preto, São Paulo, Brazil