Mechanical Versus Alcohol Epithelial Debridement During Hotorefractive Keratectomy (PRK)
Phase 2
Completed
- Conditions
- MyopiaRefractive Error
- Registration Number
- NCT00918697
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
In this prospective randomized clinical trial, confocal microscopy was used to evaluate the effect of mechanical versus alcohol-assisted epithelial debridement during photorefractive keratectomy (PRK)on corneal cellular elements. Sixty-six eyes of 33 subjects with a spherical equivalent less than -4.00 D who completed all follow-up visits were evaluated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 33
Inclusion Criteria
- spherical equivalent ≤ -4.0 D
- cylinder ≤ 1.50 D
Exclusion Criteria
- history of ocular trauma or surgery
- any corneal and ocular pathologies
- central corneal thickness < 500 µm
- scotopic pupil diameter > 6.0 mm
- any abnormalities in corneal plain or elevation topographies favoring keratoconus or other ectatic disorders
- the presence of systemic disorders such as collagen vascular diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Corneal cellular elements. Confocal microscopic findings of corneal cellular elements.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular changes occur in corneal epithelium after mechanical versus alcohol-assisted debridement in PRK for myopia?
How does alcohol-assisted epithelial removal in PRK compare to mechanical methods in terms of corneal nerve preservation and regeneration?
Are there specific corneal biomarkers that predict healing outcomes following PRK with different epithelial debridement techniques?
What are the long-term safety and efficacy profiles of alcohol-assisted versus mechanical epithelial debridement in myopic PRK patients?
How do epithelial debridement techniques in PRK influence corneal sensitivity and neurotrophic complications in refractive error correction?
Trial Locations
- Locations (1)
Ophthalmic Research Center
🇮🇷Tehran, Iran, Islamic Republic of
Ophthalmic Research Center🇮🇷Tehran, Iran, Islamic Republic of