Adipokine Genetic Variations in predictingNAFLD Progression to NASH in Egyptian Patients
Completed
- Conditions
- NAFLDNASH - Nonalcoholic Steatohepatitis
- Interventions
- Genetic: DNA extraction
- Registration Number
- NCT04561895
- Lead Sponsor
- Cairo University
- Brief Summary
Due to the limited data concerning Egyptian population. authors aimed to investigate the differentadipokine gene polymorphism related to non alcoholic fatty liver disease incidence, prognosis and progression to steotosis and also to find different related factors including obesitu, diabetes and liver enzymes level
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 224
Inclusion Criteria
Egyptian patients confirmed NAFLD diagnosis diabetic
Exclusion Criteria
- Pregnancy and lactation, history of alcohol abuse (as defined by an average daily consumption of alcohol > 30 g/day in men and > 20 g/day women), cirrhosis, autoimmune hepatitis and other causes of liver disease (viral hepatitis, hemochromatosis, Wilson's disease), drug induced hepatitis, chronic enteropathies, Chronic kidney disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description control group DNA extraction healthy volunteers with absence of NAFLD test group DNA extraction patients with confirmed NAFLD diagnosis
- Primary Outcome Measures
Name Time Method investigate adipokine dna polymorphism 1 months to investigate adipokine gene polymorphism associated with prognosis of NAFLD patients
correlations 1 month to correlate between gene polymorphism and glycated hemoglobin, liver enzyme and obesity
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
El Sahel teaching hospital
🇪🇬Cairo, Shobra, Egypt