The continuum between healthy ageing and idiopathic Parkinson Disease within a propagation perspective of inflammation and damage: the search for new diagnostic, prognostic and therapeutic targets.

Conditions: G20
Parkinson disease

Registration Number: DRKS00009427

Lead Sponsor: IRCCS Istituto delle Scienze Neurologiche di Bologna

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 15900

Inclusion Criteria

For PD patients:
1. Male and female patients older than 18 years;

For healthy controls:
1. Male and female patients older than 18 years;
2. Adhesion to the study after signature of a written informed consent.

For long-lived subjects:
1. Subjects >100 years old
2. Siblings >90 years old

Exclusion Criteria

For PD patients:
1. Patients with parkinsonian syndromes with different etiology (cerebro-vascular diseases, iatrogenic, infective, malformative or metabolic);

For healthy controls:
1. Subjects affected by cardiovascular diseases (coronary heart diseases, previous coronary stenting implantations..);
2. Subjects affected by psychiatric disorders;
3. Subjects affected by systemic, kidney, liver, or pulmonary diseases.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify biomarkers for early diagnosis of Parkinson disease.<br>This study is a multi-center study intended to perform multi-omic (genomics, epigenomics, transcriptomics, metabolomics, proteomics, lipidomics, glycomics) and validation analysis on samples from PD patients, long-lived subjects and healthy controls already recruited from 1992 to 2014.

Secondary Outcome Measures