Ketoacid ingestion along with protein to attenuate muscle catabolism during hemodialysis

Completed

• Conditions: Eiwitmetabolisme in het hele lichaam; Muscle wasting; protein-energy wasting syndrome; 10028302

• Registration Number: NL-OMON51089
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

- Aged >18 years
- Ability to provide written informed consent
- Hemodialysis treatment for >3 months
- Well-functioning arteriovenous shunt in upper or lower arm

Exclusion Criteria

- Hospitalization <1 months prior to study period
- Missed hemodialysis procedure <1 month prior to study period
- Active inflammatory disease / malignancies
- Uncontrolled hypertension (>200/100mm Hg) or arrhythmia
- Previous episodes of intradialytic hypotension related to food intake
- Allergies to milk proteins
- Dysphagia
- Pregnancy
- Cognitive disorders

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint in this study will be the net AA balance over the forearm,<br /><br>calculated by subtracting the venous from arterial AA concentrations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters include plasma and breath<br /><br>L-(ring-13C6)-phenylalanine enrichments and AA concentrations in spent<br /><br>dialysate. </p><br>