Can a ketone drink increase ATP in the brains of patients with Parkinson's disease?

Not Applicable

Completed

• Conditions: Parkinson’s disease; Nervous System Diseases; Parkinson disease

• Registration Number: ISRCTN10531043
• Lead Sponsor: TdeltaS Ltd

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-12-07
• Study Completion: 2019-12-01
• Last Update Posted: 25 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. Diagnosis of Parkinson's disease
2. Hoehn and Yahr stages 1-2
3. Fluent in English
4. Capable of giving informed consent
5. Aged 40-80

Exclusion Criteria

1. Communication impairments
2. Contraindications for undergoing magnetic resonance imaging (metal implants, claustrophobia)
3. Any disorder that the Principal Investigator deems may bias the study results or put the participant at risk

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebral ATP levels measured by 31-P MRS before and one hour after ingestion of the ketone supplement

Secondary Outcome Measures

Name	Time	Method
Glucose, insulin, free fatty acid, and beta-hydroxybutyrate levels measured by standard laboratory blood assays before and one hour after ingestion of the ketone supplement