Anesthetic Efficacy of Liposomal Prilocaine in Maxillary Infiltration Anesthesia
- Registration Number
- NCT01073371
- Lead Sponsor
- University of Campinas, Brazil
- Brief Summary
This blinded randomized, crossover, three period study aim to evaluate the anesthetic efficacy of liposome-encapsulated 3% prilocaine compared to 3% plain prilocaine and 3% prilocaine with 0,03IU/mL felypressin, after 1.8mL infiltration in the buccal sulcus of the maxillary right canine, in 32 volunteers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
- good health
- no history of allergy to the components of the local anesthetic formulations tested
- maxillary canine, lateral incisor, and first premolar responsible to electric stimulation
Exclusion Criteria
- intake of any medication that would alter pain perception
- history of trauma or sensitivity, caries, restorations, periodontal disease and endodontic treatment in the maxillary canine, lateral incisor, and first premolar
- systemic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description liposome-encapsulated 3% prilocaine Prilocaine - 3% plain prilocaine Prilocaine - 3% prilocaine with 0,03IU/mL felypressin Prilocaine -
- Primary Outcome Measures
Name Time Method Anesthesia success, onset and duration of pulpal and gingival anesthesia. 10 minutes
- Secondary Outcome Measures
Name Time Method Injection pain - Visual Analogue Scale 1 minute after the injections
Trial Locations
- Locations (1)
Piracicaba Dental School
🇧🇷Piracicaba, SP, Brazil