Basic and clinical research of pathogenesis of hip pai
Not Applicable
- Conditions
- Osteoarthritis of the hip Femoral neck fracture
- Registration Number
- JPRN-UMIN000001335
- Lead Sponsor
- Department of Orthopaedic Surgery, Graduate school of Medicine, Chiba University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
1) Past history of hip trauma, osteonecrosis of the femoral head, rheumatoid arthritis, and rapidly destructive coxarthritis 2) Previous hip surgery 3) Heart failure, respiratory dysfunction, hepatic insufficiency, and renal failure 4) Unfavorable patient condition 5) Inappropriate patient
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In basic research, synovium, limbus, femoral head and acetabulum are stained with neuron-specific class III beta-tubulin (TuJ-1), isolectin B4 (IB4), calcitonin gene-related peptide (CGRP), transient receptor potential (TRP), tromyosin receptor kinase (Trk), tumor necrosis factor-alpha (TNFa), nuclear factor-kappa B (NFkB), and p55TNF receptor. Qualitative and quantitative assessments are performed between osteoarthritis and femoral neck fracture. In clinical research, distribution and incidence of hip pain are evaluated as well as referred pain. Association of hip pain, immunohistchemistry, and image findings are analyzed.
- Secondary Outcome Measures
Name Time Method