The Influence of Mitochondrial Derived Reactive Oxygen Species on Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 早期 1 期
- 状态
- 终止
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Change in Skeletal Muscle Oxygenation
研究概览
简要总结
Cardiovascular health is a critical problem in patients with chronic obstructive pulmonary disease (COPD). Existing literature suggests oxidative stress from the mitochondria c driving some of the poor health outcomes in COPD. MitoQ is a mitochondrial-targeted antioxidant that has shown promise in improving cardiovascular outcomes in similar populations. Thus the purpose of this study is to test if MitoQ can improve cardiovascular health in COPD.
详细描述
In this study, a mitochondria-specific antioxidant will be compared to a placebo. Participants will be assigned randomly to receive either the antioxidant or the placebo for 6 weeks. A comprehensive assessment of cardiovascular health will be conducted before and after the administration of the supplement.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinically diagnosed of COPD
- •Global Initiative for obstructive lung disease (GOLD) Stages II to IV
排除标准
- •Forced Expiratory Volume in 1 second/ Functional Vital Capacity (FEV1/FVC) >0.7
- •Heart Disease
- •Vasoactive medications
- •Uncontrolled high blood pressure
- •Fluid in lungs
- •Sleep apnea
- •Raynaud's Phenomenon
- •Gangrene of the digits
- •History of coagulation
- •Pregnant women
研究组 & 干预措施
MitoQ
Participants will take 1 pill each day for 6 weeks
干预措施: MitoQ (Drug)
Placebo
Participants will take 1 pill each day for 6 weeks
干预措施: Placebo (Other)
结局指标
主要结局
Change in Skeletal Muscle Oxygenation
时间窗: Baseline and 6 weeks
Near-infrared spectroscopy will be used to measure leg muscle oxygenation
Change in vascular function
时间窗: Baseline and 6 weeks
Flow-mediated dilation will be used to measure vasodilation in the brachial artery
Change in oxidative stress
时间窗: Baseline and 6 weeks
Blood draws will be taken to measure oxidative stress markers in the blood through electron paramagnetic resonance
次要结局
- Change in arterial stiffness(Baseline and 6 weeks)
- Change in microvascular function(Baseline and 6 weeks)