Effect of Chronic Mycoprotein Consumption, and of Its Nucleotide Content, in Uric Acid Concentrations and Other Markers of Metabolic Health in Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- Serum uric acid concentrations
研究概览
简要总结
Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI between 18 and 30
排除标准
- •On medication (except contraception)
- •Diagnosed with any metabolic or cardiovascular conditions
- •BMI < 18 or > 30
- •Dietary restrictions (vegetarians/vegans, etc.)
研究组 & 干预措施
Animal protein based diet
Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by animal products (meat and fish).
干预措施: Animal protein based diet (Other)
Low-nucleotide mycoprotein based diet
Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-depleted mycoprotein products (commercial Quorn products).
干预措施: Low-nucleotide mycoprotein based diet (Other)
High-nucleotide mycoprotein based diet
Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-rich mycoprotein products.
干预措施: High-nucleotide mycoprotein based diet (Other)
结局指标
主要结局
Serum uric acid concentrations
时间窗: Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)
次要结局
- Glycaemia and serum insulin - insulin sensitivity (oral glucose tolerance test)(Measured at baseline and after 1 week intervention (day 8))
- IL-6(Measured at baseline and after 1 week intervention (day 8))
- 24 h blood glucose homeostasis - measured using a Dexcom CGMS(Measured 5 days at baseline (habitual data) and 5 days during the intervention (days 3 - 7))
- Metabolomics (using Nuclear Magnetic Resonance - NMR)(Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8))