Comparative study between preemptive Ketamine and Dexmedetomidine with intravenous Paracetamol for post-operative analgesia in laparoscopic gynecological cancer surgeries: A Double-blinded randomized controlled trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- To compare the efficacy and safety of pre-emptive ketamine with Intravenous Paracetamol vs pre-emptive dexmedetomidine with Intravenous paracetamol for postoperative analgesia in patients undergoing laparoscopic gynaecological cancer surgeries.
研究概览
简要总结
This is a prospective, randomized, double-blind controlled trial designed to compare the efficacy and safety of preemptive intravenous ketamine with paracetamol versus intravenous dexmedetomedine with paracetamol for post- operative analgesia in female patients undergoing elective laparoscopic gynaecological cancer surgeries. The study will asses postoperative pain scores, total analgesia consumption and adverse effects associated with each intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- Female
入选标准
- •Female age 18-80 years.
- •Patients of ASA physical status 1,2 &
- •Female Undergoing elective laparoscopic gynecological cancer surgeries.
排除标准
- •Patient’s refusal to participate.
- •Patients of psychiatric disorders and unable to understand VAS and substance abuse.
- •Drug allergy.
- •Pregnant females.
- •History of any underlying cardiac, hepatic, renal dysfunction.
结局指标
主要结局
To compare the efficacy and safety of pre-emptive ketamine with Intravenous Paracetamol vs pre-emptive dexmedetomidine with Intravenous paracetamol for postoperative analgesia in patients undergoing laparoscopic gynaecological cancer surgeries.
时间窗: Immediately after extubating, 0hr, 15min, 30min, 45min, 60min, 2hour, 4hour, 8hour,12 hour, 24hour
次要结局
- 1. To compare the hemodynamic stability between two groups.
研究者
Shubham Kumar
Indira Gandhi Institute of Medical Sciences, Patna