The effect of Increasing Doses of the Flavonoid Quercetin on Blood Vessel Function and Blood Pressure

Not Applicable

Completed

• Conditions: High blood pressure; Cardiovascular disease; Cardiovascular - Hypertension

• Registration Number: ACTRN12615001338550
• Lead Sponsor: niversity of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-12-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Healthy volunteers
Living in Perth, Western Australia, and able to visit the reserach centre

Exclusion Criteria

Exclusion criteria included current or recent (less than 12 months) smoking; BMI less than 18 or greater than 35 kg/m2; history of cardiovascular or peripheral vascular disease; a systolic BPless than 100 orgreater than 160 mmHg; a diastolic BP less than 50 or greater than 100 mmHg; diagnosed diabetes, and non-diabetic individuals with fasting plasma glucose concentrationsgreater than 6 mmol/L; psychiatric illness or other major illnesses such as cancer; current or recent (within previous 6 months) significant weight loss or gain (greater than 6% of body weight) or actively trying to lose weight; alcohol intake greater than 210g per week for women and greater than 280 g per week for men; and women who are lactating, pregnant or wishing to become pregnant during the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endothelial dysfunction assessed as percentage change in flow-mediated dilatation (FMD) of the brachial artery using ultrasonography[60 minutes post intervention]

Secondary Outcome Measures

Name	Time	Method
Change in office blood pressure assessed using a sphygmomanometer[60 minutes post intervention];Plasma nitric oxide status assessed by measuring plasma concentrations of nitrate and nitrite by gas chromatography/mass spectrometry [90 minutes post intervention];Plasma quercetin metabolites assessed using liquid chromatography/mass spectrometry[90 minutes]