Maternal-fetal Immune Responses to Fetal Surgery

Active, not recruiting

• Conditions: Spina Bifida; Congenital Diaphragmatic Hernia; Lower Urinary Tract Obstructive Syndrome; Myelomeningocele

• Registration Number: NCT04484441
• Lead Sponsor: Mayo Clinic

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-7-20
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Inclusion Criteria for study group:<br><br> - Maternal age =18 years<br><br> - Pregnant with a congenital anomaly diagnosis AND undergoing fetal intervention in<br> utero<br><br> - Delivery planned at Mayo Clinic, Rochester MN<br><br>Inclusion Criteria for control group:<br><br> - Maternal age =18 years<br><br> - Pregnant with normal ultrasound findings<br><br> - Delivery planned at Mayo Clinic, Rochester MN<br><br>Exclusion Criteria:<br><br> - Delivery planned elsewhere<br><br> - Abnormal fetal karyotype

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Maternal T cell activation following in utero intervention.

Secondary Outcome Measures

Name	Time	Method
Placental histology in the maternal-fetal interface in term and preterm fetal intervention cases