Development, Standardisation and Standardisation Project for a New Memory Assessment

Recruiting

• Conditions: Memory Disorders
• Interventions: Other: New memory assessment

• Registration Number: NCT06564779
• Lead Sponsor: University Hospital, Tours

Brief Summary

Episodic memory (EM) is a neuropsychological marker of Alzheimer's disease (AD) (Thomas-Anterion, 2006). Current tests for its assessment do not take into account the identity and emotional aspects of memory (Van der Linden et al., 2018). However, there are models that integrate links with identity, self-awareness and experience. Pause et al. (2013) propose criteria to create ecological tools, including consideration of the emotional valence of memories and the spatio-temporal context of acquisition. In line with these criteria, we have developed a new tool: the NEM (New evaluation of Episodic Memory). Preliminary studies show different response profiles on the NEM among patients (Launay et al., 2023). We now want to evaluate the relevance of this tool in the differential diagnosis of AD.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-08-19
• Study First Submitted QC: 2024-08-19
• Study First Posted: 2024-08-21
• Study Start: 2024-11-22
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-04
• Last Update Posted: 2024-12-09
• Primary Completion: 2028-11
• Study Completion: 2028-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Age ≥ 50 years
• Ability to understand judged sufficient by the assessor;
• Amnesic MCI profile (Petersen, 2003) during the 1st medical consultation prior to the assessment being prescribed.

Exclusion Criteria

• Severe auditory and/or visual sensory impairment not compatible with neuropsychological assessment;
• Judged fit to take the test by the assessor;
• Patient under guardianship, curatorship or family guardianship;
• Opposition to data processing.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
group intervention	New memory assessment	patients benefiting from the new memory assessment

Primary Outcome Measures

Name	Time	Method
Score total NEM (new memory assessment)	baseline	Sum of the episodic elements

Secondary Outcome Measures

Name	Time	Method
Total RL/RI 16 Recall	baseline	(Van der Linden et al., 2014)
NEM sub-scores	baseline	Sum of the episodic elements by category
Delayed Mem Logic Recall	baseline	(MEM IV, Wechsler, 2014)

Trial Locations

Locations (1)

University hospital; 🇫🇷 Tours, France