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Clinical Trials/NCT05962879
NCT05962879
Recruiting
Not Applicable

Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Massachusetts General Hospital1 site in 1 country70 target enrollmentMarch 22, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Anxiety Disorders
Sponsor
Massachusetts General Hospital
Enrollment
70
Locations
1
Primary Endpoint
Structured Interview of Psychosis-risk Syndromes (SIPS)
Status
Recruiting
Last Updated
4 months ago

Overview

Brief Summary

This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.

Registry
clinicaltrials.gov
Start Date
March 22, 2024
End Date
July 31, 2027
Last Updated
4 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Nicole DeTore, PhD

Assistant Professor

Massachusetts General Hospital

Eligibility Criteria

Inclusion Criteria

  • Currently enrolled in 9th through 12th grade and between the ages of 14 and 19
  • Endorsed at least one psychotic experience
  • Provided contact information
  • Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18)
  • Have a parent or legal guardian who is able and willing to participate in a parent session
  • Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older)
  • Able to communicate in English

Exclusion Criteria

  • Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence
  • Currently obtaining psychotherapeutic intervention

Outcomes

Primary Outcomes

Structured Interview of Psychosis-risk Syndromes (SIPS)

Time Frame: 1 year

Subclinical psychotic symptoms that represent a risk of transdiagnostic mental illnesses. This semi-structured interview rates psychotic experiences, general symptoms, and functioning. The SIPS interview assesses positive, negative, disorganized, and general symptoms. The range of the Scale of Psychosis-risk Symptoms (SOPS) is 0-6, with a higher score representing more severe symptoms.

Secondary Outcomes

  • Child Behavior Checklist (CBCL)(1 year)
  • Global Functioning Social and Role Scales(1 year)

Study Sites (1)

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