Carotenoid Response to the Intake of Vegetables and Fruits

Not Applicable

Completed

• Conditions: Resonance Raman Spectroscopy for Dietary Carotenoid Intake
• Interventions: Other: Carotenoid Depletion; Other: Carotenoid Repletion; Other: Natural Repletion

• Registration Number: NCT01403844
• Lead Sponsor: USDA Grand Forks Human Nutrition Research Center

Brief Summary

The purpose of this study is to validate the non-invasive tool, resonance Raman spectroscopy for assessing vegetable and fruit consumption.

Detailed Description

This study will validate the use of resonance Raman spectroscopy to assess vegetable and fruit intake by performing a controlled feeding study during which volunteers will consume a provided diet with known amounts of carotenoids in the form of fruits and vegetables.

Study Timeline

• Study Start: 2011-06
• Study First Submitted: 2011-07-21
• Study First Submitted QC: 2011-07-26
• Study First Posted: 2011-07-27
• Primary Completion: 2012-09
• Study Completion: 2012-09
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-18
• Last Update Posted: 2020-05-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Men and women aged 18 - 65 years
• Weight stable (±5 lbs) for at least 2 months prior to the start of the study
• Body mass index (BMI) between 19-30 kg/m2
• Willing to refrain from the use of nicotine and dietary supplements for the duration of the study
• Willing to maintain baseline weight and physical activity levels

Exclusion Criteria

1. BMI greater than 30.
2. Gastrointestinal disorders, disease, or medication that affects carotenoid absorption or storage
3. Current smoker
4. Allergies or intolerances to foods to be utilized in the study
5. Consumption of greater than an average of 1 alcoholic drink/day for women and 2/day for men, use of nutritional/sports supplements (if unwilling to discontinue during the study)
6. Pregnancy or lactating

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Skin Carotenoids	Carotenoid Depletion	Skin carotenoids will be measured under conditions of depletion or repletion
Skin Carotenoids	Carotenoid Repletion	Skin carotenoids will be measured under conditions of depletion or repletion
Skin Carotenoids	Natural Repletion	Skin carotenoids will be measured under conditions of depletion or repletion

Primary Outcome Measures

Name	Time	Method
Serum and skin levels of carotenoids in adults fed a high carotenoid diet	28 weeks

Trial Locations

Locations (1)

Grand Forks Human Nutrition Research Center; 🇺🇸 Grand Forks, North Dakota, United States