A multicenter randomized clinical trial investigating the cost-effectiveness of treatment strategies with or without antibiotics for uncomplicated acute diverticulitis.

Academic Medical Center, department of Surgery0 个研究点目标入组 534 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

•1. Only left-sided uncomplicated (mild) acute diverticulitis;
•2. Clinical suspicion of acute diverticulitis. For acute diagnostic work-up: ultrasound or CT proven diverticulitis. In the case of diverticulitis-negative ultrasound in clinically suspected patients an intravenous contrast-enhanced CT scan is mandatory for confirmation of diverticulitis or exclusion of other pathology. CT for Hinchey/Ambrosetti classification (which is a CT-based classification system) is needed for all patients, but can be delayed 1 day in those with ultrasound diagnosis. Staging diverticultis is defined according the modified Hinchey/Ambrosetti staging, only stages 1a and 1b and mild diverticulitis (1a Confined pericoloc inflammation, 1b Confined small (smaller than 5cm) pericolic abscess) are included. In the attachments we have added a flow chart, showing systematically the inclusion criteria and the following steps after inclusion;

•1. Previous radiological (ultrasound and/or CT) proven episode of diverticulitis;
•2. Colonic cancer;

发起方

Academic Medical Center, department of Surgery