Post Exercise Substrate Oxidation, Appetite and Energy Intakes in Overweight/Obese Postmenopausal Women (EScAPE)

Not Applicable

Completed

• Conditions: Postmenopausal; Overweight
• Interventions: Other: Moderate Intensity Continuous Exercise; Other: High-Intensity Interval Exercise (1); Other: High-Intensity Interval Exercise (2)

• Registration Number: NCT04364061
• Lead Sponsor: Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

Brief Summary

High-intensity interval exercise (HIIT), as compared to moderate intensity continuous training (MICT), is a time-efficient strategy to decrease total and abdominal fat mass (FM). However, the mechanisms underlying such adaptations are not yet elucidated and research are still needed to establish the optimal HIIT according to subject characteristics. The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, appetite and energy intakes over 24h in postmenopausal women with overweight or obesity. It is hypothesized that compared with the traditional MICE, HIIE could favor greater enjoyment, higher 2h-post-exercise fat oxidation and a similar energy intakes over 24h despite different post-exercise appetite perceptions.

Detailed Description

The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, and appetite and energy intakes over 24h in postmenopausal women with overweight or obesity.

Using a randomized crossover design, 12 postmenopausal women completed 3 cycling exercises at 6-days intervals:

i) Moderate Intensity Continuous Exercise (MICE) which consisted of 35 min cycling at 60-65% theorical Peak Heart Rate (thPHR) ii) High Intensity Interval Exercise 1 (HIIE 1) 60 cycles of speeding up for 8 s at 80-90%thPHR followed by pedaling slowly for 12 s (20min) iii) High Intensity Interval Exercise 2 (HIIE 2) which consisted of repeated 10 x 1min at 80-90% thPHR followed by pedaling slowly for 1min.

Substrate oxidation (CHO and FAT) were measured at rest and 2h- post exercise. Enjoyment, perceived exertion and appetite were recorded and post-exercise energy intakes were assessed over 24h.

Study Timeline

• Study Start: 2019-11-01
• Status Verified: 2020-04
• Primary Completion: 2020-04-01
• Study Completion: 2020-04-01
• Study First Submitted: 2020-04-21
• Study First Submitted QC: 2020-04-24
• Last Update Submitted: 2020-04-26
• Study First Posted: 2020-04-27
• Last Update Posted: 2020-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 12

Inclusion Criteria

• postmenopausal women (spontaneous amenorrhea for at least 12 months)
• with overweight or obesity (BMI > 25 kg/m2 and ≤ 40 kg/m2)

Exclusion Criteria

• medical contraindications to intense physical activity,
• painful joints,
• taking hormone replacement therapy,
• taking B-blockers.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Women with overweight or obesity	Moderate Intensity Continuous Exercise	-
Women with overweight or obesity	High-Intensity Interval Exercise (2)	-
Women with overweight or obesity	High-Intensity Interval Exercise (1)	-

Primary Outcome Measures

Name	Time	Method
Post-exercise (2 hours) CHO and FAT oxidation	2 hours post-exercise	CHO and FAT oxidation were measured after each modality with indirect calorimetry during 2 hours post-exercise

Secondary Outcome Measures

Name	Time	Method
Enjoyment	Immediately post-exercise	Perceive enjoyment evaluated with Physical Activity Enjoyment Scale (PAES) for each modalities. The total scores of PAES are between 18 and 126 with the higher scores indicating greater enjoyment.
Rate Perceive Exertion (RPE)	During exercise (5-10-15 and 20 minutes for HIIE1 and 2 ; 9-18-27 and 35 minutes for MICE) which corresponds at 25-50-75 and 100% of bout completion.	RPE evaluated with adapted Borg's Scale during exercise for each modalities
Appetite	Before, immediately post-exercise, 60 minutes and 120 minutes post-exercise	The validated 100 millimeters Visual Analogue Scale (VAS) was used to assess the subjective appetite at 4 time points: before, immediately post-exercise, 60 minutes and 120 minutes post-exercise. This scale comprised four questions anchored with words representing the opposing extreme states of desire to eat, hunger, fullness and prospective food consumption. The score of each question are between 0 and 100.
Energy intakes	24 hours post-exercise	Estimated energy intakes using dietary questionnaires

Trial Locations

Locations (1)

CREPS Auvergne Rhône-Alpes / Vichy; 🇫🇷 Bellerive-sur-Allier, Allier, France