High Interval Versus Moderate Intensity Continuous Training on Soluble st2 Biomarkers in Chronic Heart Failure

Not Applicable

Completed

• Conditions: Heart Failure

• Registration Number: NCT06647667
• Lead Sponsor: Cairo University

Brief Summary

This study was designed to compare between the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on soluble ST2 biomarkers among chronic heart failure patients, also measure the improvement in the quality of life with different modes of exercise and with of it is more benifitial for the heart failure patient

Detailed Description

The data concerned with the study including soluble ST2 biomarker levels, ejection fraction and MLHFQ was measured before and after twelve weeks of treatment.In this study a total sixty male patients with chronic heart failure NYHA class (I \&II) were selected from the outpatient clinic, El-Demerdash hospital, Ain-shams University. Their age ranged from 50-60 years. Patients were randomly assigned into two groups, group A receiving HIIT along with prescribed medical treatment and group B receiving MCT along with prescribed medical treatment.

Study Timeline

• Study Start: 2022-09-15
• Primary Completion: 2023-08-20
• Study Completion: 2023-10-16
• Study First Submitted: 2024-06-14
• Status Verified: 2024-10
• Study First Submitted QC: 2024-10-15
• Last Update Submitted: 2024-10-15
• Study First Posted: 2024-10-18
• Last Update Posted: 2024-10-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• The patients selection was according to the following criteria:

  • Patients diagnosed with chronic heart failure (New York heart association class I& II) with systolic left ventricular dysfunction.
  • Their left ventricular ejection fraction (LVEF) <40%.
  • Medical treatment was optimized at least three months prior to study entry.
  • All patients didn't participate in any rehabilitation programs prior to the study.

Exclusion Criteria

• Patients who had met one of the following criteria were excluded from the study:

  1. Signs of acute heart failure, unstable angina or severe arrhythmia three months prior to enrolment in the study.
  2. Pacemakers.
  3. Chronic obstructive pulmonary disease.
  4. Other disorders counteracting exercise testing conditions that limit lower limb mobility (for example, burns, fractures)
  5. Pre-existing neuromuscular diseases (for example Myasthenia Gravis).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
soluble ST2 biomarker level	before the start of the trail and at the end of the trail 3 months	sample was taken at the cubited vein at the beginning of the program and also at its end

Secondary Outcome Measures

Name	Time	Method
ejection fraction	before the start of the trail and at the end of the trail 3 months	Left ventricular systolic dysfunction was assessed using the ejection fraction by 2D simpson method
mannisota of daily living questionnaire score	before the start of the trail and at the end of the trail 3 months	The twenty one item questionnaire was usedfrom 0 (none) to 5 (very much). It provides a total score (range 0-105, from best to worst HRQoL), as well as scores for two dimensions, physical (8 items, range 0-40) and emotional (5 items, range 0-25). The other eight items (of the total of 21) are only considered for the calculation of the total score.
peak exercise response	before the start of the trail and at the end of the trail 3 months	monitoring the peak exercise response

Trial Locations

Locations (1)

Faculty of physical therapy Cairo University; 🇪🇬 Giza, Egypt