NCT01010815Unknown不适用
Metagenomic Analysis of Gut Microbiome in Korean Patients With Ulcerative Colitis
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- characterize the difference in gut microbiomes through metagenomic analysis between UC patients and normal control subjects
研究概览
简要总结
The researchers will investigate gut microbiome in Korean patients with ulcerative colitis and normal control subjects using metagenomic analysis to elucidate the significant difference between two groups This study will help to understand the association between gut microbiome and inflammatory bowel disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the age of 19 and 75 years
- •willing to consent/undergo necessary procedures
- •clinically active or inactive Ulcerative colitis
排除标准
- •Inability to provide informed consent or
- •Clinically severe or fulminant ulcerative colitis
- •Previous abdominal surgery
- •Pregnancy
- •Clinically or laboratory-confirmed gastroenteritis for at least 3 months before sampling
- •the use of antibiotics in the past a month before sampling
- •the use of probiotics in the past a month before sampling
- •Severe cardiovascular or pulmonary disease
- •Severe convulsive disorder and current use of anti-convulsive medication
- •Malignancy
- •Transplantation
结局指标
主要结局
characterize the difference in gut microbiomes through metagenomic analysis between UC patients and normal control subjects
时间窗: 1 year
次要结局
- characterize the difference in gut microbiomes through metagenomic analysis between stool specimens and biopsy specimens in participants with UC and normal subjects(1 year)
- characterize the difference in gut microbiomes among colonoscopy biopsy locations (rectum, ascending and descending colon)(1 year)
- characterize the difference in gut microbiomes between active and inactive UC patients(1 year)
研究者
研究点 (1)
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