The Effect of Long-pulsed 1064 nm nd: Yag Laser-assisted Hair Removal on Some Skin Flora and Pathogens: an in Vivo Study

Not Applicable

• Conditions: Changes in Bacterial Count in Axilla After Laser Hair Removal
• Interventions: Device: ND;YAG 1064NM LASER

• Registration Number: NCT05034237
• Lead Sponsor: Alexandria University

Brief Summary

1. To evaluate the effect of ND-YAG laser hair removal on some skin flora and pathogens: an in vivo study.

2. To determine the immediate and long term effect of ND-YAG laser on total viable bacterial count, some skin flora and pathogens of laser-assisted hair removal in axilla.

3. To assess the relation between this effect and bromohidrosis.

Detailed Description

This Quasi-experimental interrupted time series study will be conducted on 30 female participants who will be recruited from the Dermatology Outpatient Clinic of the Alexandria Main University Hospital.

Four sessions of laser assisted hair removal at 4 weeks intervals (S1, S2, S3 and S4) using long pulsed ND: YAG (Cynosure Elite+™, Westford, USA). The following parameters will be used according to the nature of hair (1064 nm, 15-18 mm spot size, fluence of 24-35 J/cm2, pulse duration 30-40 ms).

4. Swabs will be collected immediately and after each session

Study Timeline

• Study Start: 2021-01-14
• Study First Submitted: 2021-07-23
• Status Verified: 2021-08
• Study First Submitted QC: 2021-08-28
• Last Update Submitted: 2021-08-28
• Study First Posted: 2021-09-05
• Last Update Posted: 2021-09-05
• Primary Completion: 2022-01
• Study Completion: 2022-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

No previous laser hair removal sessions involving axilla. Fitzpatrick skin type III-VI.

Exclusion Criteria

1. Skin diseases such as atopic dermatitis, psoriasis, fungal or herpetic infections.
2. Systemic diseases such as diabetes or endocrinal dysfunction.
3. Patients receiving immunosuppressive therapy.
4. Pregnant or lactating females.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
ND;YAG 1064 NM LASER	ND;YAG 1064NM LASER	monthly sessions of laser hair removal

Primary Outcome Measures

Name	Time	Method
to compare changes in bacterial count and composition of axillary flora after laser hair removal	4 month	counting bacterial colonies (aerobic,anaerobic,lipophyllic and staphylococcal) using colony counter

Secondary Outcome Measures

Name	Time	Method
To assess the relation between this effect and bromohidrosis.	4 month	using a questionnaire that is categorized into better , worse or unchanged sweat odour.
To determine the immediate and long term effect of ND-YAG laser on total viable bacterial count, some skin flora and pathogens of laser-assisted hair removal in axilla	4 month	counting bacterial colonies immediately before and immediately after each laser session

Trial Locations

Locations (1)

Alexandria University Faculty of Medicine; 🇪🇬 Alexandria, Egypt