Identification and characterization of pruritus pathways in chronic skin inflammatio

Recruiting

• Conditions: L43; L29.8; Atopic dermatitis; Psoriasis; Lichen planus; Other pruritus; L40; Chronic pruritus; L20

• Registration Number: DRKS00015168
• Lead Sponsor: niversitätsklinik für Dermatologie und Allergologie, Klinikum Oldenburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 270

Inclusion Criteria

Patients with chronic pruritus (due to lichen planus, psoriasis and atopic dermatitis); minimum age 18 years

Exclusion Criteria

Patients who cannot complete the questionnaires due to physical or psychiatric diseases or an insufficient understanding of the German language. Patients taking antipruritic drugs. Patients with an infection at the potential biopsy area. Patients who received anti-inflammatory therapy within the last two weeks and pregnant or breast-feeding women are excluded from the study.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
expression profiles of pruritic mediators (immunohistochemistry and immunofluorescence, ELISA, Western Blot)<br>gene expression profiles (qPCR, RNA sequencing)<br>Patient questionnaires: NeuroDerm questionnaire, 5PLQ, SF12, Beck´s Depression Inventory (BDI), Trait anxiety inventory (STAI-T), Self-Administered Comorbidity Questionnaire (SCQ), Brief Pain Inventory (BPI), Pain Catastrophizing Scale, Neuropathic pain symptom inventory (NPSI)

Secondary Outcome Measures

Name	Time	Method
better understanding of the pruritus pathways