Comparing the efficacy of Nidepine and Cardepine in lowering blood pressure after cardio-aortic surgery: a randomized, double-blinded controlled trial
Phase 3
Completed
- Conditions
- We carried out prospective randomized double blind controlled trial in a cardio vascular thoracic intensive care unit (ICU). Patients who underwent cardiac or aortic arch surgery were enrolled and conHypertension Cardiac surgery Calcium channel blocker Nicardepine
- Registration Number
- TCTR20190206003
- Lead Sponsor
- niversal Medical Industry, Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Patients aged more than 18 years’ old who underwent a cardiac or an aortic arch surgery were enrolled and continuously observed for blood pressure during their admission in the intensive care unit. Those with post-operative hypertension, defined as systolic blood pressure > 140 mmHg.
Exclusion Criteria
Patients were excluded from the study if there were any of these criteria: supine heart rate > 150 beats/min or supraventricular tachycardia during the immediate post-operative period, sternal drain output > 200 ml in the first hour, hypercarbia (pCO2 > 40 mmHg), clinically significant hepatic disease, recent cerebrovascular accident within the past 3 months, allergic or intolerant to CCB or pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood pressure lowering 15 min and 30 min after start treatment Blood pressure level after start treatment
- Secondary Outcome Measures
Name Time Method Post operative complication Until discharge from ICU Event and hospital stay