Effects of Auditory Stimulation on Sleep and Memory in Schizophrenia
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Schizophrenia
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Differences in slow-oscillation spindle coupling
- Status
- Active, Not Recruiting
- Last Updated
- last year
Overview
Brief Summary
The investigators will test the hypothesis that auditory stimulation (playing quiet sounds during sleep) can normalize brain activity during sleep and improve memory in patients with schizophrenia. The investigators will do this by measuring sleep and memory performance under two conditions separated by one week: receiving auditory stimulation during sleep and not receiving auditory stimulation during sleep. The investigators will study healthy subjects and outpatients with schizophrenia.
Investigators
Dara S. Manoach, PhD
Professor
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •For healthy controls:
- •Male and female subjects
- •18-50 years of age
- •Proficient in English
- •For schizophrenia patients:
- •Male and female schizophrenia outpatients
- •18-50 years of age
- •Proficient in English
- •Able to give informed consent
Exclusion Criteria
- •Pregnant females
- •Current use of psychotropic medications (healthy controls only)
- •A history of head injury resulting in prolonged loss of consciousness or other neurological sequelae
- •Neurological disorder (including seizure disorder)
- •Significant hearing or vision loss
- •Current substance abuse or dependence (nicotine abuse or dependence is not exclusionary)
- •Any unstable chronic medical condition that affects sleep
- •Diagnosed sleep disorder
Outcomes
Primary Outcomes
Differences in slow-oscillation spindle coupling
Time Frame: Placebo and auditory stimulation naps will be approximately one week apart
Differences in slow oscillation-spindle coupling during non-rapid eye movement (NREM) sleep as measured by EEG between placebo and auditory stimulation naps
Secondary Outcomes
- Differences in slow oscillations(Placebo and auditory stimulation naps will be approximately one week apart)
- Differences in sleep spindles(Placebo and auditory stimulation naps will be approximately one week apart)
- Differences in sleep-dependent consolidation of motor procedural memory(Placebo and auditory stimulation naps will be approximately one week apart)