To compare the effect of dexmedetomidine drug through two different routes of administration on suppressing intubation response.
Not Applicable
- Conditions
- Health Condition 1: 4- Measurement and Monitoring
- Registration Number
- CTRI/2019/04/018416
- Lead Sponsor
- Dr Megha V
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients who have given written informed consent
2. Patients with ASA grade I & II.
3. Patients aged 18-60 years.
4. Patients with BMI 19-28 kg/m2
5. Patients scheduled for elective surgery under general anaesthesia.
Exclusion Criteria
1. Patients not willing to give written informed consent.
2. Patients with history of allergy to dexmedetomidine..
3. Patients with anticipated difficult mask ventilation/difficult intubation.
4. Patients with baseline heart rate < 60 bpm and systolic blood pressure < 100 mm Hg
5. Patients with coronary heart disease, ischemic heart disease, heart blocks, diabetes mellitus.
6. Pregnant women/Breastfeeding mothers.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dexmedetomidine nebulisation effectively attenuates pressor response to laryngoscopy and intubation when compared to dexmedetomidine given intravenously , efficacy parameter being hemodynamic parameters ( heart rate, systolic BP, diastolic BP, mean arterial pressures, SpO2Timepoint: Baseline <br/ ><br>Before drug <br/ ><br>After drug <br/ ><br>Before induction <br/ ><br>After induction <br/ ><br>Immediate after intubation <br/ ><br>1 min after intubation <br/ ><br>2 min after intubation <br/ ><br>5 min after intubation <br/ ><br>10 min after intubation
- Secondary Outcome Measures
Name Time Method dexmedetomidine nebulisation may have lesser side effects like bradycardia, hypotension, dizziness ,post operative sedation etc.Timepoint: Intra-operative <br/ ><br>Post-operative till 2 hours