CARE-ID: Dynamics of Respiratory Infections in Children and Transmission in Households and Schools
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 500
- 试验地点
- 2
- 主要终点
- To describe the viral dynamics of influenza, RSV and SARS-CoV-2 over time among children <18 years of age.
研究概览
简要总结
Viral respiratory tract infections are very common in children. They contribute to missed time in school, work disruption for caregivers and can also cause severe illness requiring hospitalization and rarely death. In the 2022-2023, influenza, RSV and SARS-CoV-2 viruses infected a large number of children which strained the pediatric healthcare system in many jurisdictions. Unfortunately, there continues to be limited data on duration of infectiousness and transmission risk of these viruses to inform public health decisions during times when there is significant circulation of these viruses.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Day 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Viral dynamics (primary outcome):
- •The child must be less than 18 years of age
- •Have a positive PCR sample for influenza, RSV or SARS-CoV-2,
- •Have any one of the symptoms listed to meet testing eligibility: fever, cough, shortness of breath, decreased or loss of taste or smell, muscle aches/joint pains (unusual, long lasting, not related to injury), extreme tiredness (unusual fatigue not otherwise explained), sore throat, runny or stuffy/congested nose, headache (new, unusual, long-lasting), nausea/vomiting and/or diarrhea, and
- •Be within 5 days of symptom onset
- •Household testing inclusion criteria (secondary outcome):
- •Any individual in the same household (i.e. household contacts, defined as residing at the same address) as the individual testing positive by PCR for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, or bordetella pertussis
- •Classroom testing inclusion criteria (secondary outcome):
- •Any individual in the same classroom (i.e. classroom contacts) as the individual testing positive by PCR for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, or bordetella pertussis (i.e. case identified through the THS program)
排除标准
- •Viral dynamics (primary outcome):
- •Participants will be ineligible if they are more than 5 days from symptom onset
结局指标
主要结局
To describe the viral dynamics of influenza, RSV and SARS-CoV-2 over time among children <18 years of age.
时间窗: 14 days
The correlation between symptom onset and symptom resolution and viral load for each virus will be described.
次要结局
- To assess the impact of various host factors on viral dynamics(14 days)
- To assess the frequency of influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae and bordetella pertussis transmission in households.(Within 14 days of case identification)
- To examine the risk factors for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae and bordetella pertussis transmission in households(Within 14 days of case identification)
- To assess the frequency of influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae and bordetella pertussis transmission in classrooms.(Within 14 days of case identification)
- To examine the risk factors for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae and bordetella pertussis transmission in classrooms(Within 14 days of case identification)
研究者
Michelle Science
Staff Physician
The Hospital for Sick Children