Impact of Covid-19 on Rhinovirus Epidemic

• Conditions: Rhinovirus
• Interventions: Other: epidemiology

• Registration Number: NCT05348707
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Rhinovirus (RV) has long been known as the main etiological agent of "common colds" among children and adults. Indeed, RV is involved in more than 50% of upper respiratory tract infections (URTIs), mostly characterized by nasal congestion, rhinorrhea, sore throat and cough. RV can also cause mild to severe lower respiratory tract infections (LRTIs) such as acute bronchiolitis, pneumonia and exacerbations of underlying chronic lung diseases. RV circulates worldwide, especially in temperate climate zones (i.e. many areas of the USA and Europe) and is responsible for annual outbreaks from early fall to the end of spring.

The covid-19 pandemic in 2020 seemed to interfere with the usual seasonal epidemics. For example, the winter Respiratory Syncytial Virus (RSV) epidemic in Lyon, France, was delayed for several months and reduced by half in terms of incidence of hospitalization cases. This can be explained by the widespread deployment of barrier gestures and social distancing measures, known as "non pharmacological interventions" (NPI).

However, the Covid-19 pandemic doesn't seem to have the same reducing impact on Rhinovirus epidemic. A better understanding of viral interactions and factors influencing RV epidemiology as well as the identification of populations at greater risk are required to improve preventive strategies and reduce the burden of Rhinovirus.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2022-02
• Study First Submitted: 2022-02-17
• Study First Submitted QC: 2022-04-26
• Last Update Submitted: 2022-04-26
• Study First Posted: 2022-04-27
• Last Update Posted: 2022-04-27
• Study Start: 2022-05
• Primary Completion: 2023-04
• Study Completion: 2023-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• • Child hospitalized at the " Hopital Femme Mere Enfant ", Lyon, France
• Positive rhinovirus-PCR

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Exclusion Criteria

• • parent's refusal to participate

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pre Covid 19 cohort	epidemiology	Infants hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a RT-PCR positive for Rhinovirus from 17th March 2019 to 16th March 2020.
Per Covid 19 cohort year 1	epidemiology	Infant hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a RT-PCR positive for Rhinovirus from 17th March 2020 to 16th March 2021. The need to recruit patients for an additional per-covid year (from 17th March 2021 to 16th March 2022) will be evaluated after the data from the first 2 years of recruitment are available.
Per Covid 19 cohort, year 2	epidemiology	Infants hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a RT-PCR positive for Rhinovirus from 17th March 2021 to 16th March 2022. The need to recruit patients for this additional cohort will be evaluated after the data from the first 2 years of recruitment are available and analyzed.

Primary Outcome Measures

Name	Time	Method
Evolution of the number of children hospitalized for a Rhinovirus-infection in the period of pre Covid-19 pandemic.	From one year before the SARS-CoV-2 pandemic until the beginning of the SARS-CoV-2 pandemic	Description of number of clinical picture cases for pre-SARS-CoV-2 pandemic year.
Evolution of the number of children hospitalized for a Rhinovirus-infection in the period of per-Covid-19 pandemic.	From the beginning of the SARS-CoV-2 pandemic until one year latter	Description of number of clinical picture cases for per-SARS-CoV-2 pandemic year.