Viral Dynamics and Transmission of Influenza, RSV and SARS-CoV-2 in Children
- Conditions
- SARS CoV 2 InfectionRSV InfectionInfluenza
- Registration Number
- NCT06640387
- Lead Sponsor
- The Hospital for Sick Children
- Brief Summary
Viral respiratory tract infections are very common in children. They contribute to missed time in school, work disruption for caregivers and can also cause severe illness requiring hospitalization and rarely death. In the 2022-2023, influenza, RSV and SARS-CoV-2 viruses infected a large number of children which strained the pediatric healthcare system in many jurisdictions. Unfortunately, there continues to be limited data on duration of infectiousness and transmission risk of these viruses to inform public health decisions during times when there is significant circulation of these viruses.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 500
Viral dynamics (primary outcome):
- The child must be less than 18 years of age
- Have a positive PCR sample for influenza, RSV or SARS-CoV-2,
- Have any one of the symptoms listed to meet testing eligibility: fever, cough, shortness of breath, decreased or loss of taste or smell, muscle aches/joint pains (unusual, long lasting, not related to injury), extreme tiredness (unusual fatigue not otherwise explained), sore throat, runny or stuffy/congested nose, headache (new, unusual, long-lasting), nausea/vomiting and/or diarrhea, and
- Be within 5 days of symptom onset
Household testing inclusion criteria (secondary outcome):
-Any individual in the same household (i.e. household contacts, defined as residing at the same address) as the individual testing positive by PCR for influenza, RSV or SARS-CoV-2
Classroom testing inclusion criteria (secondary outcome):
-Any individual in the same classroom (i.e. classroom contacts) as the individual testing positive by PCR for influenza, RSV or SARS-CoV-2 (i.e. case identified through the THS program)
Viral dynamics (primary outcome):
-Participants will be ineligible if they are more than 5 days from symptom onset
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To describe the viral dynamics of influenza, RSV and SARS-CoV-2 over time among children <18 years of age. 10 days The correlation between symptom onset and symptom resolution and viral load for each virus will be described.
- Secondary Outcome Measures
Name Time Method To assess the impact of various host factors on viral dynamics 10 days The correlation between host factors and viral dynamics will be explored.
To assess the frequency of influenza, RSV and SARS-CoV-2 transmission in households. Within 14 days of case identification The number of household contacts that are tested and test positive for the same respiratory virus (influenza, RSV or SARS-CoV-2) will be described.
To examine the risk factors for influenza, RSV and SARS-CoV-2 transmission in households Within 14 days of case identification The correlation between household characteristics and transmission of each of the viruses will be explored.
To assess the frequency of influenza, RSV and SARS-CoV-2 transmission in classrooms. Within 14 days of case identification The number of classmates in the classroom that are tested and test positive for the same respiratory virus (influenza, RSV or SARS-CoV-2) will be described.
To examine the risk factors for influenza, RSV and SARS-CoV-2 transmission in classrooms Within 14 days of case identification The correlation between classroom characteristics and transmission of each virus in classrooms will be explored.
Trial Locations
- Locations (1)
The Hospital for Sick Children (SickKids)
🇨🇦Toronto, Ontario, Canada