Effect of S-Ketamine on Body Perception in Healthy Adults
- Conditions
- The research will be conducted with healthy volunteers and no patients are involved.10027946
- Registration Number
- NL-OMON53181
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
1. Healthy male or female volunteers; 2. Age: 18 - 40 years; 3. Body mass index
< 30 kg/m2 4. Able to give informed consent. 5. Be able to speak and understand
English.
Exclusion Criteria
1. Known or suspected neuromuscular or a (family) history of any neuromuscular
disease 2. A history of allergic reaction to food or medication including study
medication 3. Any current or previous medical (including high blood pressure),
neurological or psychiatric illness (including a history of anxiety) 4. Alcohol
abuse (> 21 units/week) 5. Illicit drug use in the past 30 days before
inclusion 6. Pregnancy or lactation 7. Participation in any medical or drug
trial in the month prior to the current study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measures are the neural and behavioral effects of<br /><br>S-ketamine relative to placebo. Specifically, we examine the neural effects of<br /><br>S-ketamine on event-related potentials (ERPS) in a sensory suppression task and<br /><br>in a trait-adjective task. Additionally, we examine the effects of S-ketamine<br /><br>on perception of peripersonal space, feelings of feelings of embodiment and<br /><br>perception of heart rate, through behavioral-experimental tasks and<br /><br>measurements. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary outcome measures of this study are the effects of S-ketamine on<br /><br>subjective perception, measured by questionnaires and an interview; the<br /><br>relationship between the subjective measures and neural and behavioral effects;<br /><br>and the relationship between personality factors and subjective effects. </p><br>