NCT04948957已完成不适用
Changes in Cerebral Oxygenation and Cognitive Functions During Controlled Hypotension
Zonguldak Bulent Ecevit University1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2014年3月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- effects of controlled hypotension on cerebral oxygen saturation
研究概览
简要总结
The present study aimed to assess the influence of nitroglycerin and esmolol-induced hypotension on cerebral oxygen saturation by using near-infrared spectroscopy and postoperative cognitive function in patients undergoing nasal surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •written informed consent
- •patients with ASA physical status of I-II
- •aged 18-65 years
排除标准
- •Age under 18 or above 65
- •ASA > II
- •coagulation disorders
- •history of cardiovascular and cerebrovascular disease
- •poor Blood Pressure control
- •anemia, pregnancy, addiction to opioids
- •body mass index (BMI) > 35
- •intraoperative systolic BP < 65 mmHg
- •surgical duration less than 30 minutes or more than 160 minutes
- •need for an intraoperative sympathomimetic drug and the use of other hypotensive drugs
- •preoperative Mini-Mental State Examination (MMSE) score of 23 or less.
研究组 & 干预措施
esmolol (Group E)
干预措施: Esmolol (Drug)
nitroglycerin (Group N)
干预措施: Nitroglycerin (Drug)
结局指标
主要结局
effects of controlled hypotension on cerebral oxygen saturation
时间窗: until end of the surgical procedure.
influence of nitroglycerin and esmolol-induced hypotension on cerebral oxygen saturation by measuring regional cerebral oxygen saturation using Near-Infrared Spectroscopy
次要结局
- effects of controlled hypotension on cognitive function(24 hour before surgery and 24 hour after surgery)
研究者
Bengü Gülhan Aydin
Associate Professor
Zonguldak Bulent Ecevit University
研究点 (1)
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