Effect of incentive spirometry in prevention of acute chest syndrome during painful crisis in adult sickle cell patients

• Conditions: sickle cell anemia; sickling of the lungs; 10018902

• Registration Number: NL-OMON34975
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

High performance liquid chromatography confirmed diagnosis of HbSS, HbSC, HbSB0- or HbSB+-thalassemia genotypes.
Written informed consent by the patient.
Thoracic or back pain above the diaphragm.
Hospital admission due to vaso-occlusive painful crisis.

Exclusion Criteria

Blood transfusion in the preceding three months
Diagnosis of Acute Chest Syndrome at presentation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. To evaluate the efficacy of incentive spirometry in primary prevention of<br /><br>ACS in adult sickle cell patients during painful crisis.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. To relate the efficacy of incentive spirometry to plasma levels of<br /><br>phospholipase A2 and serum levels of procalcitonine.<br /><br><br /><br>2. To evaluate whether plasma sPLA2 levels may be helpful to stratify patients<br /><br>in high and low risk groups and to evaluate the value of incentive spirometry<br /><br>in these groups to prevent ACS.<br /><br><br /><br>3. To evaluate whether serum procalcitonine may stratify patients with an ACS<br /><br>related to an infectious and non-infectious pathogenesis and to evaluate the<br /><br>value of incentive spirometry to prevent ACS.<br /><br><br /><br>4. To identify the micro bacterial organisms responsible for the development of<br /><br>an acute chest syndrome and to relate this with the procalcitonin plasma<br /><br>levels.</p><br>