A Study to Evaluate Rocatinlimab (AMG 451) in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)
- Conditions
- Atopic Dermatitis
- Interventions
- Drug: Placebo
- Registration Number
- NCT05704738
- Lead Sponsor
- Amgen
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of rocatinlimab in monotherapy and combination therapy treatment in adolescent participants.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 500
- Age ≥ 12 to < 18 years at Day 1.
- Diagnosis of AD (according to American Academy of Dermatology Consensus Criteria [Eichenfield et al, 2014]) that has been present for at least 12 months before signing of informed consent.
- Body weight ≥ 40 kg at screening.
- History of inadequate response to TCS of medium to higher potency (with or without TCI).
- EASI score ≥ 12 at initial screening.
- EASI score ≥ 16 at Day 1.
- vIGA-AD score ≥ 3.
- ≥10% body surface area of AD involvement.
- Worst pruritus NRS ≥ 4.
-
Treatment with a biological product within 12 weeks or 5 half-lives, whichever is longer, prior to Day 1.
-
Treatment with any of the following medications or therapies within 4 weeks or 5 half-lives, whichever is longer, prior to Day 1:
- Systemic corticosteroids
- Non-biologic, non-targeted systemic immunosuppressants
- Phototherapy
- Oral or Topical Janus kinase inhibitors
-
Treatment with any of the following medications or therapies within 1 week, prior to Day 1:
- TCS of any potency
- TCI
- Topical phosphodiesterase 4 inhibitors
- Other topical immunosuppressive agents
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Arm A: Dose 1 Rocatinlimab Part 1 (Initial Period); Week 0 to Week 24: Rocatinlimab Dose 1 every 4 weeks (Q4W) for 24 weeks with loading dose at Week 2 (+ topical corticosteroids (TCS)/ topical calcineurin inhibitor (TCI) if within combination therapy cohort). Part 2 (Maintenance Period); Week 24 to Week 52: Part 1 Responders will be rerandomised at Week 24 to Rocatinlimab Dose 1 Q4W or every 8 weeks (Q8W) for 28 weeks (+ TCS/TCI if within combination therapy cohort). Arm C: Placebo Placebo Part 1 (Initial Period); Week 0 to Week 24: Placebo Q4W for 24 weeks with loading dose at Week 2 (+TCS/TCI if within combination therapy cohort). Part 2 (Maintenance Period); Week 24 to Week 52: Part 1 Responders will be reassigned at Week 24 with Placebo Q4W for 28 weeks (with TCS/TCI if within combination therapy cohort). Arm B: Dose 2 Rocatinlimab Part 1 (Initial Period); Week 0 to Week 24: Rocatinlimab Dose 2 Q4W for 24 weeks with loading dose at Week 2 (+TCS/TCI if within combination therapy cohort). Part 2 (Maintenance Period); Week 24 to Week 52: Part 1 Responders will be rerandomised at Week 24 to Rocatinlimab Dose 2 Q4W or Q8W for 28 weeks (with TCS/TCI if within combination therapy cohort). Arm D: Open-Label Dose 1 Rocatinlimab Part 2; Week 24 to Week 52: Part 1 Non-Responders will be reassigned at Week 24 with Rocatinlimab Open-label Dose 1 Q4W for 28 weeks (with TCS/TCI if within combination therapy cohort). Participants in Arms A, B or C Maintenance Period will be reassigned with Rocatinlimab Open-label Dose 1 Q4W (with TCS/TCI if within combination therapy cohort) upon relapse after Week 24.
- Primary Outcome Measures
Name Time Method Achievement of a Validated Investigator's Global Assessment for Atopic Dermatitis Score of 0 (Clear) or 1 (Almost Clear) with a ≥ 2 Point Reduction From Baseline (vIGA-AD 0/1) at Week 24 Baseline and Week 24 Achievement of ≥ 75% Reduction From Baseline in EASI Score (EASI 75) at Week 24 Baseline and Week 24
- Secondary Outcome Measures
Name Time Method Change From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 24 Baseline and Week 24 Change From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 16 Baseline and Week 16 Achievement of EASI 75 at Week 16 Baseline and Week 16 Achievement of a vIGA-AD 0/1 at Week 16 Baseline and Week 16 Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of Daily Worst Pruritus Numeric Rating Scale (NRS) Score at Week 16 in Participants with Baseline Weekly Average of Daily Worst Pruritus NRS Score ≥ 4 Baseline and Week 16 Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 24 in Participants with Baseline Weekly Average of Daily Worst Pruritus NRS Score ≥ 4 Baseline and Week 24 Achievement of ≥ 90% Reduction From Baseline in EASI Score (EASI 90) at Week 24 Baseline and Week 24 Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of AD Skin Pain NRS Score at Week 24 in Participants with Baseline Weekly Average of AD Skin Pain NRS Score ≥ 4 Baseline and Week 24 Achievement of a vIGA-AD Score of 1 with Presence of Only Barely Perceptible Erythema or vIGA-AD Score of 0 (revised Investigator's Global Assessment [rIGA™] 0/1) at Week 24 Baseline and Week 24 Initiation of rescue therapy for AD at or before Week 16 Baseline to Week 16 Initiation of rescue therapy for AD at or before Week 24 Baseline to Week 24 Change From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 16 Baseline to Week 16 Change From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 24 Baseline to Week 24 Change From Baseline in Scoring of Atopic Dermatitis (SCORAD) Itch Visual Analog Scale (VAS) Score at Week 16 Baseline to Week 16 Change From Baseline in SCORAD Itch VAS Score at Week 24 Baseline to Week 24 Achievement of a ≥ 4-point Reduction from Baseline in Dermatology Life Quality Index (DLQI) Score at Week 24 in Participants with Baseline DLQI ≥ 4 in Participants ≥ 16 Years of Age at Enrollment Baseline and Week 24 Change From Baseline in DLQI Score at Week 24 in Participants ≥ 16 Years of Age at Enrollment Baseline to Week 24 Change From Baseline in CDLQI Score at Week 24 in Participants < 16 Years of Age at Enrollment Baseline to Week 24 Achievement of a ≥ 4-point Reduction From Baseline in Patient Oriented Eczema Measure (POEM) Score at Week 24 in Participants with Baseline POEM Score ≥ 4 Baseline and Week 24 Change From Baseline in POEM Score at Week 24 Baseline to Week 24 Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 16 in Participants with Baseline Weekly Average of Daily AD Skin Pain NRS Score ≥ 4 Baseline and Week 16 Achievement of a ≥ 3-point Reduction From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 24 in Participants with Baseline Weekly Average of Daily AD Skin Pain NRS Score ≥ 3 Baseline and Week 24 Achievement of a ≥ 3-point Reduction From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 16 in Participants with Baseline Weekly Average of Daily AD Skin Pain NRS Score ≥ 3 Baseline and Week 16 Change From Baseline in Weekly Average of Sleep Disturbance NRS Score at Week 24 Baseline to Week 24 Achievement of a Hospital Anxiety and Depression Scale (HADS)-anxiety Subscale Score < 8 at Week 24 in Participants with Baseline HADS-anxiety Subscale Score ≥ 8 Baseline and Week 24 Change From Baseline in HADS-anxiety Subscale Score at Week 24 Baseline to Week 24 Achievement of a HADS-depression Subscale Score < 8 at Week 24 in Participants with Baseline HADS-depression Subscale Score ≥ 8 Baseline and Week 24 Change From Baseline in HADS-depression Subscale Score at Week 24 Baseline to Week 24 Achievement of a ≥ 8.7-point Reduction from Baseline in Severity SCORAD Score at Week 24 in Participants with Baseline SCORAD Score ≥ 8.7 Baseline and Week 24
Trial Locations
- Locations (246)
Suizenji Dermatology Clinic
🇯🇵Kumamoto-shi, Kumamoto, Japan
Yoshioka Dermatology Clinic
🇯🇵Neyagawa-shi, Osaka, Japan
Dermatology and Ophthalmology Kume Clinic
🇯🇵Sakai-shi, Osaka, Japan
Royalderm Agnieszka Nawrocka
🇵🇱Warszawa, Poland
Dermatologiczna Praktyka Lekarska Michal Torz Dermaceum Centrum Badan Klinicznych
🇵🇱Wroclaw, Poland
Clinical Research of Puerto Rico
🇵🇷San Juan, Puerto Rico
Gcm Medical Group, Psc
🇵🇷San Juan, Puerto Rico
Dr Leventer Centre Clinica Dermatologie Bucuresti
🇷🇴Bucharest, Romania
Derma Cluj
🇷🇴Cluj-Napoca, Romania
Institutul Regional de Gastroenterologie si Hepatologie Prof Dr Octavian Fodor
🇷🇴Cluj-Napoca, Romania
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Cataluña, Spain
Nanyang First Peoples Hospital
🇨🇳Nanyang, Henan, China
The Central Hospital of Wuhan
🇨🇳Wuhan, Hubei, China
Cahaba Dermatology and Skin Health Center
🇺🇸Birmingham, Alabama, United States
AllerVie Clinical Research- Cullman
🇺🇸Cullman, Alabama, United States
Eclipse Clinical Research
🇺🇸Tucson, Arizona, United States
Arkansas Research Trials, LLC
🇺🇸North Little Rock, Arkansas, United States
Center for Dermatology Clinical Research Inc
🇺🇸Fremont, California, United States
Doc1 Healthcare Systems Incorporated
🇺🇸Fullerton, California, United States
Axon Clinical Research
🇺🇸Inglewood, California, United States
Avance Clinical Trials
🇺🇸Laguna Niguel, California, United States
Cura Clinical Research
🇺🇸Palmdale, California, United States
Integrative Skin Science and Research
🇺🇸Sacramento, California, United States
University of California at Davis Medical Center
🇺🇸Sacramento, California, United States
Allergy and Asthma Medical Group and Research Center
🇺🇸San Diego, California, United States
University of California at San Diego Rady Childrens Hospital San Diego
🇺🇸San Diego, California, United States
Clinical Science Institute
🇺🇸Santa Monica, California, United States
Cura Clinical Research Sherman Oaks
🇺🇸Sherman Oaks, California, United States
Velocity Clinical Research - Denver
🇺🇸Denver, Colorado, United States
Childrens National Medical Center
🇺🇸Washington, District of Columbia, United States
Clinical Research of Brandon
🇺🇸Brandon, Florida, United States
Corazon United States of America, LLC doing business as Life Clinical Trials
🇺🇸Coral Springs, Florida, United States
Academic Alliance in Dermatology - Saint Petersburg Office
🇺🇸Clearwater, Florida, United States
Palm Beach Dermatology Group
🇺🇸Delray Beach, Florida, United States
Direct Helpers Research Center
🇺🇸Hialeah, Florida, United States
Glick Skin Institute
🇺🇸Margate, Florida, United States
Deluxe Health Care LLC
🇺🇸Miami Lakes, Florida, United States
Savin Medical Group LLC
🇺🇸Miami Lakes, Florida, United States
Angels Clinical Research Institute
🇺🇸Miami Lakes, Florida, United States
Miami Clinical Research
🇺🇸Miami, Florida, United States
ara Professionals Limited Liability Corporation
🇺🇸Miami, Florida, United States
Optimal Research Sites, LLC
🇺🇸Orange City, Florida, United States
Clinical Associates of Orlando Limited Liability Company
🇺🇸Orlando, Florida, United States
Clinical Research Investments
🇺🇸Orlando, Florida, United States
University of South Florida
🇺🇸Tampa, Florida, United States
Centricity Research Columbus
🇺🇸Columbus, Georgia, United States
Advanced Medical Research PC
🇺🇸Sandy Springs, Georgia, United States
Divine Dermatology and Aesthetics
🇺🇸Savannah, Georgia, United States
McIntosh Clinic PC
🇺🇸Thomasville, Georgia, United States
Treasure Valley Medical Research
🇺🇸Boise, Idaho, United States
Velocity Clinical Research - Boise
🇺🇸Meridian, Idaho, United States
NorthShore University HealthSystem Clinical Trials Center
🇺🇸Skokie, Illinois, United States
Dawes Fretzin Clinical Research Group, LLC
🇺🇸Indianapolis, Indiana, United States
Southern Indiana Clinical Trials
🇺🇸New Albany, Indiana, United States
The Indiana Clinical Trials Center PC
🇺🇸Plainfield, Indiana, United States
Equity Medical
🇺🇸Bowling Green, Kentucky, United States
Kentucky Advanced Medical Research LLC
🇺🇸Murray, Kentucky, United States
Industrial Medicine Associates Clinical Research Advanced Dermatology Care
🇺🇸Monroe, Louisiana, United States
Aesthetic and Dermatology Center
🇺🇸Rockville, Maryland, United States
Derm Associates, PC
🇺🇸Rockville, Maryland, United States
Oakland Hills Dermatology
🇺🇸Auburn Hills, Michigan, United States
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
Onyx Clinical Research
🇺🇸Flint, Michigan, United States
MediSearch Clinical Trials
🇺🇸Saint Joseph, Missouri, United States
Saint Louis University
🇺🇸Saint Louis, Missouri, United States
Somnos Clinical Research
🇺🇸Lincoln, Nebraska, United States
Skin Cancer and Dermatology Institute
🇺🇸Reno, Nevada, United States
Allcutis Research
🇺🇸Portsmouth, New Hampshire, United States
The Dermatology Center of New Jersey
🇺🇸Bridgewater, New Jersey, United States
University of New Mexico
🇺🇸Albuquerque, New Mexico, United States
Yeshiva University - Montefiore Medical Center
🇺🇸Bronx, New York, United States
Ace Clinical Trials
🇺🇸Brooklyn, New York, United States
Empire Dermatology
🇺🇸East Syracuse, New York, United States
Smart Medical Research Inc
🇺🇸Jackson Heights, New York, United States
Forest Hills Dermatology Group
🇺🇸Kew Gardens, New York, United States
Pioneer Clinical Research New York
🇺🇸New York, New York, United States
Cornell University - Weill Cornell Medicine
🇺🇸New York, New York, United States
Rochester Clinical Research
🇺🇸Rochester, New York, United States
Duke South Durham
🇺🇸Durham, North Carolina, United States
Optima Research
🇺🇸Boardman, Ohio, United States
Apex Clinical Research Center LLC
🇺🇸Mayfield Heights, Ohio, United States
Epic Medical Research - Oklahoma
🇺🇸Chickasha, Oklahoma, United States
Lynn Health Science Institute
🇺🇸Oklahoma City, Oklahoma, United States
Dermatology and Aesthetics of Oklahoma
🇺🇸Oklahoma City, Oklahoma, United States
Dermatology Research Center of Oklahoma, PLLC
🇺🇸Tulsa, Oklahoma, United States
Essential Medical Research LLC
🇺🇸Tulsa, Oklahoma, United States
Velocity Clinical Research - Grants Pass
🇺🇸Grants Pass, Oregon, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
Paddington Testing Company Inc
🇺🇸Philadelphia, Pennsylvania, United States
Rhode Island Hospital, Lifespan
🇺🇸Providence, Rhode Island, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
National Allergy and Asthma Research, LLC
🇺🇸North Charleston, South Carolina, United States
Coastal Pediatric Research
🇺🇸Summerville, South Carolina, United States
HealthStar Physicians Dermatology
🇺🇸Morristown, Tennessee, United States
The University of Texas Health Science Center at Houston
🇺🇸Bellaire, Texas, United States
US Dermatology Partners Cedar Park
🇺🇸Cedar Park, Texas, United States
Studies in Dermatology LLC
🇺🇸Cypress, Texas, United States
MedCare Pharma - Houston
🇺🇸Houston, Texas, United States
Tranquil Clinical Research
🇺🇸Houston, Texas, United States
Sante Clinical Research
🇺🇸Kerrville, Texas, United States
Long and Harris Dermatology
🇺🇸Lubbock, Texas, United States
Sms Clinical Research Limited Liability Company
🇺🇸Mesquite, Texas, United States
Sienna Dermatology Research
🇺🇸Missouri City, Texas, United States
Texas Dermatology and Laser Specialists
🇺🇸San Antonio, Texas, United States
Epiphany Dermatology
🇺🇸Southlake, Texas, United States
Pioneer Research Solutions
🇺🇸Sugar Land, Texas, United States
Tanner Clinic
🇺🇸Murray, Utah, United States
Dermatology Research of Utah, dba Providence Dermatology
🇺🇸Providence, Utah, United States
Jordan Valley Dermatology Center
🇺🇸South Jordan, Utah, United States
Maria M Ona MD PC
🇺🇸Franklin, Virginia, United States
Northwest Clinical Research Center
🇺🇸Bellevue, Washington, United States
Hopital Erasme
🇧🇪Bruxelles, Belgium
Universite Catholique de Louvain Cliniques Universitaires Saint Luc
🇧🇪Bruxelles, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
🇧🇪Liege, Belgium
Dermatologie Maldegem
🇧🇪Maldegem, Belgium
Clinica Instituto Bahiano de Imunoterapia - Medicina, Reumatologia e Dermatologia ltda
🇧🇷Salvador, Bahia, Brazil
Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo
🇧🇷Vitória, Espírito Santo, Brazil
Centro de Pesquisa Clínica da Universidade de Belo Horizonte - Unibh
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Union Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Irmandade da Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Cecip Centro Est Clin Int Paulista
🇧🇷Jau, São Paulo, Brazil
Le Plume Dermatologia- Clinica de Dermatologia Dra Beatriz Elias Eirelli
🇧🇷Ribeirão Preto, São Paulo, Brazil
Instituto Pesquisa e Ensino em Saúde Infantil
🇧🇷Sao Paulo, São Paulo, Brazil
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
🇧🇷Sao Paulo, São Paulo, Brazil
Hospital de Base de Sao Jose do Rio Preto
🇧🇷São José do Rio Preto, São Paulo, Brazil
IBPClin Instituto Brasil de Pesquisa Clinica
🇧🇷Rio de Janeiro, Brazil
Rejuvenation Dermatology Laser Calgary North
🇨🇦Calgary, Alberta, Canada
Lynderm Research Inc
🇨🇦Markham, Ontario, Canada
Dr SK Siddha Medicine Professional Corporation
🇨🇦Newmarket, Ontario, Canada
Allergy Research Canada Incorporated
🇨🇦Niagara Falls, Ontario, Canada
XLR8 Medical Research, Incorporated
🇨🇦Windsor, Ontario, Canada
Skinsense Medical Research
🇨🇦Saskatoon, Saskatchewan, Canada
Centro Dermatologico Dermisur
🇨🇱Osorno, Chile
Centro Medico Skinmed Spa
🇨🇱Santiago, Chile
Clinica Dermacross SA
🇨🇱Santiago, Chile
Fundacion Innovacion Cardiovascular
🇨🇱Santiago, Chile
Centro Internacional de Estudios Clinicos
🇨🇱Santiago, Chile
Childrens Hospital Capital Institute of Pediatrics
🇨🇳Beijing, Beijing, China
Peking University Peoples Hospital
🇨🇳Beijing, Beijing, China
Beijing Childrens Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
Peking University Third Hospital
🇨🇳Beijing, Beijing, China
Childrens Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
The First Affiliated Hospital Sun-Yat Sen University
🇨🇳Guangzhou, Guangdong, China
Dermatology Hospital of Southern Medical University
🇨🇳Guangzhou, Guangdong, China
Sun Yat-sen Memorial Hospital Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
Jiangyin Hospital of Traditional Chinese Medicine
🇨🇳Jiangyin, Jiangsu, China
The First Bethune Hospital of Jilin University
🇨🇳Changchun, Jilin, China
Dalian Women and Childrens Medical Group
🇨🇳Dalian, Liaoning, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China
Shanghai Skin Disease Hospital
🇨🇳Shanghai, Shanghai, China
Chengdu Second Peoples Hospital
🇨🇳Chengdu, Sichuan, China
Suining Central Hospital
🇨🇳Suining, Sichuan, China
Kunming Childrens Hospital
🇨🇳Kunming, Yunnan, China
Affiliated Hangzhou First Peoples Hospital School of Medicine Westlake University
🇨🇳Hangzhou, Zhejiang, China
Ningbo NO 2 Hospital
🇨🇳Ningbo, Zhejiang, China
Taizhou Central Hospital
🇨🇳Taizhou, Zhejiang, China
Hunan Childrens Hospital
🇨🇳Changsha, China
Shenzhen Childrens Hospital
🇨🇳Shenzhen, China
Special Hospital for Medical Rehabilitation Naftalan
🇭🇷Ivanic-Grad, Croatia
University Hospital Centre Osijek
🇭🇷Osijek, Croatia
Children s Hospital Zagreb
🇭🇷Zagreb, Croatia
Sestre milosrdnice University Hospital Center
🇭🇷Zagreb, Croatia
University Hospital Centre Zagreb
🇭🇷Zagreb, Croatia
Hopital Prive d Antony
🇫🇷Antony, France
Centre Hospitalier Regional Universitaire Brest Hopital Morvan
🇫🇷Brest, France
Hôpital Saint-Joseph
🇫🇷Marseille Cedex 8, France
Centre Hospitalier Universitaire de Nantes Hôtel Dieu
🇫🇷Nantes, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
🇫🇷Rennes Cedex 9, France
Centre Hospitalier Universitaire de Rouen - Hôpital Charles Nicolle
🇫🇷Rouen Cedex, France
Centre Hospitalier Universitaire de Toulouse, Hopital Larrey
🇫🇷Toulouse, France
Fachklinik Bad Bentheim
🇩🇪Bad Bentheim, Germany
Universitaetsklinikum Bonn
🇩🇪Bonn, Germany
Rosenpark Research GmbH
🇩🇪Darmstadt, Germany
Universitaetsklinikum Dresden
🇩🇪Dresden, Germany
Universitaetsklinikum Erlangen
🇩🇪Erlangen, Germany
Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universitaet Frankfurt am Main
🇩🇪Frankfurt am Main, Germany
Velocity Clinical Research
🇩🇪Leipzig, Germany
Johannes Gutenberg Universitaet Mainz
🇩🇪Mainz, Germany
Athens Naval Hospital
🇬🇷Athens, Greece
Athens General Childrens Hospital Panagioti And Aglaia Kyriakou
🇬🇷Athens, Greece
Thoracic General Hospital Of Athens Sotiria
🇬🇷Athens, Greece
Ippokratio General Hospital of Thessaloniki
🇬🇷Thessaloniki, Greece
Clinexpert Kft
🇭🇺Budapest, Hungary
Derma-B Egeszsegugyi es Szolgaltato Kft
🇭🇺Debrecen, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz
🇭🇺Kaposvar, Hungary
Soroka Medical Center
🇮🇱Bear Sheva, Israel
Sheba Medical Center
🇮🇱Ramat Gan, Israel
Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Azienda Ospedaliera Universitaria Luigi Vanvitelli
🇮🇹Napoli, Italy
Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia
🇮🇹Perugia, Italy
Presidio Molinette Azienda Ospedaliera Citta della Salute e della Scienza di Torino
🇮🇹Torino, Italy
Central Clinic
🇯🇵Nagoya-shi, Aichi, Japan
Miyata Dermatology Clinic
🇯🇵Matsudo-shi, Chiba, Japan
Matsuo Clinic
🇯🇵Fukuoka-shi, Fukuoka, Japan
Asahikawa City Hospital
🇯🇵Asahikawa-shi, Hokkaido, Japan
Takagi Dermatological Clinic
🇯🇵Obihiro-shi, Hokkaido, Japan
Yoshimura Child Clinic
🇯🇵Akashi-shi, Hyogo, Japan
Katahira Dermatology Urology Clinic
🇯🇵Kagoshima-shi, Kagoshima, Japan
Nomura Dermatology Clinic
🇯🇵Yokohama-shi, Kanagawa, Japan
Yokohama City Minato Red Cross Hospital
🇯🇵Yokohama-shi, Kanagawa, Japan
Jouzan Hihuka Hinyoukika Clinic
🇯🇵Kumamoto-shi, Kumamoto, Japan
Hamamatsu University Hospital
🇯🇵Hamamatsu-shi, Shizuoka, Japan
Naoko Dermatology Clinic
🇯🇵Setagaya-ku, Tokyo, Japan
NTT Medical Center Tokyo
🇯🇵Shinagawa-ku, Tokyo, Japan
Korea University Ansan Hospital
🇰🇷Ansansi, Gyeonggido, Korea, Republic of
Nowon Eulji Medical Center, Eulji University
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
National Medical Center
🇰🇷Seoul, Korea, Republic of
Kyung Hee University Hospital at Gangdong
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St Marys Hospital
🇰🇷Seoul, Korea, Republic of
Chung-Ang University Hospital
🇰🇷Seoul, Korea, Republic of
Hallym University Kangnam Sacred Heart Hospital
🇰🇷Seoul, Korea, Republic of
Ewha Womans University Seoul Hospital
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Phylasis Clinicas Research Toluca
🇲🇽Toluca, Mexico
Uniwersyteckie Centrum Kliniczne
🇵🇱Gdansk, Poland
AKK Medical Spolka z ograniczona odpowiedzialnoscia Centrum Medyczne Tu sie leczy
🇵🇱Gdansk, Poland
GynCentrum Sp zoo NZOZ Holsamed
🇵🇱Katowice, Poland
Centrum Medyczne Angelius Provita
🇵🇱Katowice, Poland
Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski Pawel Brzewski SpCywilna
🇵🇱Krakow, Poland
Diamond Clinic Spolka z Ograniczona Odpowiedzialnoscia Diamond Medical Center
🇵🇱Krakow, Poland
AppleTreeClinics Network Spzoo
🇵🇱Lodz, Poland
Amicare Spolka z ograniczona odpowiedzialnoscia Spolka Komandytowa Amicare Centrum Medyczne
🇵🇱Lodz, Poland
Clinical Best Solutions Sp zoo Spolka Komandytowa
🇵🇱Lublin, Poland
Centrum Zdrowia Dziecka i Rodziny Im Jana Pawla II w Sosnowcu Osrodek Badan Klinicznych
🇵🇱Sosnowiec, Poland
Alergo-Med Specjalistyczna Przychodnia Lekarska Spzoo
🇵🇱Tarnow, Poland
Klinika Osipowicz and Turkowski Sp zoo
🇵🇱Warszawa, Poland
High Med Przychodnia Specjalistyczna
🇵🇱Warszawa, Poland
Klinika Ambroziak Dermatologia
🇵🇱Warszawa, Poland
Hospital Sant Joan de Deu
🇪🇸Esplugues de Llobregat, Cataluña, Spain
Clinica Universidad de Navarra
🇪🇸Pamplona, Navarra, Spain
Hospital General Universitario Gregorio Maranon
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Linkou Chang Gung Memorial Hospital
🇨🇳Taoyuan, Taiwan
King Chulalongkorn Memorial Hospital
🇹🇭Bangkok, Thailand
Siriraj Hospital
🇹🇭Bangkok, Thailand
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Thailand
Thammasat University Hospital
🇹🇭Pathum Thani, Thailand