A Study Assessing Rocatinlimab in Combination With Topical Corticosteroid and/or Topical Calcineurin Inhibitors in Adult Participants With Moderate-to-severe Atopic Dermatitis (AD)
- Registration Number
- NCT05724199
- Lead Sponsor
- Amgen
- Brief Summary
The coprimary objectives of the study are to:
* evaluate the efficacy of rocatinlimab in combination with topical corticosteroid and/or topical calcineurin inhibitor (TCS/TCI), compared with placebo in combination with TCS/TCI at Week 24, assessed using Validated Investigator's Global Assessment for Atopic Dermatitis (vIGA-AD™).
* evaluate the efficacy of rocatinlimab, in combination with TCS/TCI, compared with placebo in combination with TCS/TCI at Week 24, assessed using Eczema Area and Severity Index (EASI).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 746
- Age ≥ 18 years with a diagnosis of AD according to the AAD (American Academy of Dermatology) Consensus Criteria (2014) present for at least 12 months
- History of inadequate response to TCS of medium or higher potency (with or without TCI)
- EASI score ≥16
- vIGA-AD score ≥3
- ≥10% body surface area (BSA) of AD involvement
- Worst pruritus numerical rating scale ≥ 4
-
Treatment with a biological product within 12 weeks or 5 half-lives, whichever is longer, prior to Day 1
-
Treatment with any of the following medications or therapies within 4 weeks or 5 half-lives, whichever is longer, prior to Day 1:
- Systemic corticosteroids
- Nonbiologic, non-targeted Systemic immunosuppressants
- Phototherapy
- Janus kinase inhibitors
-
Treatment with any of the following medications or therapies within 1 week, prior to Day 1:
- TCS
- TCI
- Topical phosphodiesterase type 4 inhibitors
- Other topical immunosuppressive agents
- Combination topical agents including TCS of any potency or TCI, PDE4 inhibitors, or other topical immunosuppressive agents
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Rocatinlimab Dose 2 + TCS/TCI Rocatinlimab Rocatinlimab Dose 2 Q4W for 24 weeks + TCS/TCI + loading dose at Week 2. Placebo + TCS/TCI Placebo Placebo Q4W for 24 weeks + TCS/TCI + loading dose at Week 2. Rocatinlimab Dose 1 + TCS/TCI Rocatinlimab Rocatinlimab Dose 1 every 4 weeks (Q4W) for 24 weeks + TCS/TCI + loading dose at Week 2.
- Primary Outcome Measures
Name Time Method Achievement of a vIGA-AD Score of 0 or 1 with a ≥2 Point Reduction From Baseline at Week 24 Baseline, Week 24 Achievement of ≥ 75% Reduction From Baseline in EASI Score (EASI 75) at Week 24 Baseline, Week 24
- Secondary Outcome Measures
Name Time Method Change from Baseline in DLQI Score at Week 24 Baseline, Week 24 Achievement of ≥ 90% Reduction From Baseline in EASI Score (EASI 90) at Week 24 Baseline, Week 24 Achievement of EASI 75 at Week 16 Baseline, Week 16 Achievement of vIGA-AD 0/1 at Week 16 Baseline, Week 16 Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of Daily Worst Pruritus Numeric Rating Scale (NRS) Score at Week 16 in Participants with Baseline Weekly Average of Daily Worst Pruritus NRS Score ≥ 4 Baseline, Week 16 Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 24 in Participants with Baseline Weekly Average of Daily Worst Pruritus NRS Score ≥ 4 Baseline, Week 24 Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of AD Skin Pain NRS Score at Week 24 in Participants With Baseline Weekly Average of AD Skin Pain NRS Score ≥ 4 Baseline, Week 24 Achievement of vIGA-AD 1 Response with a Presence of Only Barely Perceptible Erythema or vlGA-AD 0 Response (Revised IGA [rIGA™] 0/1) at Week 24 Baseline, Week 24 Achievement of a Facial AD Severity Score of Clear at Week 24 for Participants with Facial AD at Baseline Baseline, Week 24 Achievement of a Hand AD Severity Score of Clear at Week 24 for Participants with Hand AD at Baseline Baseline, Week 24 Change From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 16 Baseline, Week 16 Change From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 24 Baseline, Week 24 Change From Baseline in SCORing Atopic Dermatitis (SCORAD) Itch Visual Analogue Scale (VAS) Score at Week 16 Baseline, Week 16 Change From Baseline in SCORAD Itch VAS Score at Week 24 Baseline, Week 24 Achievement of ≥ 4-point Reduction From Baseline in Dermatology Life Quality Index (DLQI) Score at Week 24 in Participants With Baseline DLQI Score ≥ 4 Baseline, Week 24 Achievement of a ≥ 4-point Reduction From Baseline in Patient Oriented Eczema Measure (POEM) Score at Week 24 in Participants with Baseline POEM Score ≥ 4 Baseline, Week 24 Change From Baseline in POEM Score at Week 24 Baseline, Week 24 Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of AD Skin Pain NRS Score at Week 16 in Participants With Baseline Weekly Average of AD skin pain NRS Score ≥ 4 Baseline, Week 16 Change From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 24 Baseline, Week 24 Change From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 16 Baseline, Week 16 Achievement of a ≥ 3-point Reduction From Baseline in Weekly Average of AD Skin Pain NRS Score at Week 24 in Participants With Baseline Weekly Average of AD Skin Pain NRS Score ≥ 3 Baseline, Week 24 Achievement of a ≥ 3-point Reduction From Baseline in Weekly Average of AD Skin Pain NRS Score at Week 16 in Participants With Baseline Weekly Average of AD Skin Pain NRS Score ≥ 3 Baseline, Week 16 Change From Baseline in Weekly Average of Sleep Disturbance NRS Score at Week 24 Baseline, Week 24 Achievement of a Hospital Anxiety and Depression Scale (HADS)-anxiety Subscale Score < 8 at Week 24 in Participants with Baseline HADS-anxiety Subscale Score ≥ 8 Baseline, Week 24 Achievement of a HADS-depression Subscale Score < 8 at Week 24 in Participants with Baseline HADS-depression Subscale Score ≥ 8 Baseline, Week 24 Achievement of a ≥ 8.7-point Reduction from Baseline in SCORAD Score at Week 24 in Participants with Baseline SCORAD Score ≥ 8.7 Baseline, Week 24 Change From Baseline in HADS-anxiety Subscale Score at Week 24 Baseline, Week 24 Change From Baseline in HADS-depression Subscale Score at Week 24 Baseline, Week 24
Trial Locations
- Locations (233)
Csalogany Orvosi Kozpont
🇭🇺Budapest, Hungary
Clinexpert Kft
🇭🇺Budapest, Hungary
Obudai Egeszsegugyi Centrum Kft
🇭🇺Zalaegerszeg, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Gyongyosi Bugat Pal Korhaz
🇭🇺Gyongyos, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz
🇭🇺Kaposvar, Hungary
DermaMed Research Kft
🇭🇺Oroshaza, Hungary
Allergo-Derm Bakos Kft
🇭🇺Szolnok, Hungary
Ospedale Policlinico San Martino IRCCS
🇮🇹Genova, Italy
Ospedale San Salvatore
🇮🇹LAquila, Italy
Univerzitetni Klinicni Center Maribor
🇸🇮Maribor, Slovenia
Centre Hospitalier Universitaire Brugmann
🇧🇪Brussels, Belgium
Salford Care Organisation
🇬🇧Salford, United Kingdom
The University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Medical Dermatology Specialists
🇺🇸Phoenix, Arizona, United States
Southwest Skin Specialists
🇺🇸Phoenix, Arizona, United States
US Dermatology Partners Sun City West
🇺🇸Sun City West, Arizona, United States
Arkansas Research Trials, LLC
🇺🇸North Little Rock, Arkansas, United States
Kern Research Inc
🇺🇸Bakersfield, California, United States
Wallace Medical Group Inc
🇺🇸Los Angeles, California, United States
Keck Medicine of University of Southern California
🇺🇸Los Angeles, California, United States
Antelope Valley Clinical Trials
🇺🇸Palmdale, California, United States
University of California at Davis Medical Center
🇺🇸Sacramento, California, United States
Kaiser Permanente South Sacramento Medical Center
🇺🇸Sacramento, California, United States
Acclaim Clinical Research
🇺🇸San Diego, California, United States
Universitair Ziekenhuis Brussel
🇧🇪Brussel, Belgium
Kaiser Permanente Medical Center - Oakland
🇺🇸San Francisco, California, United States
Kaiser Permanente Medical Center - San Francisco
🇺🇸San Francisco, California, United States
Synergy Dermatology
🇺🇸San Francisco, California, United States
TrueBlue Clinical Research
🇺🇸Tampa, Florida, United States
Olympian Clinical Research - Tampa
🇺🇸Tampa, Florida, United States
Atlanta Dermatology, Vein and Research Center, PC
🇺🇸Alpharetta, Georgia, United States
Divine Dermatology and Aesthetics
🇺🇸Atlanta, Georgia, United States
NorthShore University HealthSystem
🇺🇸Skokie, Illinois, United States
DS Research
🇺🇸Clarksville, Indiana, United States
Dawes Fretzin Clinical Research Group, LLC
🇺🇸Indianapolis, Indiana, United States
Dermatology and Skin Cancer Center Leawood
🇺🇸Leawood, Kansas, United States
Industrial Medicine Associates Clinical Research Advanced Dermatology Care
🇺🇸Monroe, Louisiana, United States
Aesthetic and Dermatology Center
🇺🇸Rockville, Maryland, United States
University of Michigan Medical Center
🇺🇸Ann Arbor, Michigan, United States
Oakland Hills Dermatology
🇺🇸Auburn Hills, Michigan, United States
Somnos Clinical Research
🇺🇸Lincoln, Nebraska, United States
Skin Specialists PC
🇺🇸Omaha, Nebraska, United States
Vivida Dermatology
🇺🇸Las Vegas, Nevada, United States
Las Vegas Clinical Trials
🇺🇸North Las Vegas, Nevada, United States
Schweiger Dermatology Group, PC Research Division
🇺🇸Hackensack, New Jersey, United States
Albuquerque Clinical Trials Incorporated
🇺🇸Albuquerque, New Mexico, United States
Chear Center LLC
🇺🇸Bronx, New York, United States
Accellacare of Wilmington
🇺🇸Wilmington, North Carolina, United States
Bexley Dermatology Research
🇺🇸Bexley, Ohio, United States
Velocity Clinical Research Inc
🇺🇸Medford, Oregon, United States
Paddington Testing Company Inc
🇺🇸Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
Health Concepts
🇺🇸Rapid City, South Dakota, United States
US Dermatology Partners Jollyville
🇺🇸Austin, Texas, United States
Newco 3A Research LLC
🇺🇸El Paso, Texas, United States
Sante Clinical Research
🇺🇸Kerrville, Texas, United States
Texas Dermatology Research Center
🇺🇸Plano, Texas, United States
Virginia Dermatology and Skin Cancer Center
🇺🇸Norfolk, Virginia, United States
Cinme - Centro de Investigaciones Metabolicas
🇦🇷Caba, Buenos Aires, Argentina
Framingham Centro Medico
🇦🇷La Plata, Buenos Aires, Argentina
Dim Clinica Privada
🇦🇷Ramos Mejia, Buenos Aires, Argentina
Buenos Aires Skin SA
🇦🇷Ciudad Autonoma de Buenos Aires, Distrito Federal, Argentina
Fundacion Cidea
🇦🇷Ciudad Autonoma de Buenos Aires, Distrito Federal, Argentina
Care- Centro de Alergia y Enfermedades Respiratorias
🇦🇷Ciudad Autonoma de Buenos Aires, Distrito Federal, Argentina
Psoriahue Medicina Interdisciplinaria SRL
🇦🇷Ciudad Autonoma de Buenos Aires, Distrito Federal, Argentina
Centro de Investigaciones Clinicas Instituto Especialidades De La Salud De Rosario
🇦🇷Rosario, Santa Fe, Argentina
Emeritus Research Sydney
🇦🇺Botany, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
The Skin Centre
🇦🇺Benowa, Queensland, Australia
Princess Alexandra Hospital
🇦🇺South Brisbane, Queensland, Australia
Veracity Clinical Research
🇦🇺Woolloongabba, Queensland, Australia
Emeritus Research Melbourne
🇦🇺Camberwell, Victoria, Australia
Medizinische Universitaet Graz
🇦🇹Graz, Austria
Medizinische Universitaet Innsbruck
🇦🇹Innsbruck, Austria
Landeskrankenhaus Salzburg
🇦🇹Salzburg, Austria
Klinik Landstrasse
🇦🇹Wien, Austria
Klinik Hietzing
🇦🇹Wien, Austria
Algemeen Ziekenhuis Sint-Jan Brugge-Oostende
🇧🇪Brugge, Belgium
Universite Catholique de Louvain Cliniques Universitaires Saint Luc
🇧🇪Bruxelles, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Clinique Andre Renard
🇧🇪Herstal, Belgium
Dermatologie Handelskaai
🇧🇪Kortrijk, Belgium
Universitaire Ziekenhuizen Leuven Gasthuisberg
🇧🇪Leuven, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
🇧🇪Liege, Belgium
Grand Hopital de Charleroi
🇧🇪Loverval, Belgium
Medical Center Asklepii OOD
🇧🇬Dupnitsa, Bulgaria
Medical Center Medconsult Pleven OOD
🇧🇬Pleven, Bulgaria
Medical Center Excelsior OOD
🇧🇬Sofia, Bulgaria
Diagnostic-Consultative Center Alexandrovska EOOD
🇧🇬Sofia, Bulgaria
Diagnostic-Consultative Center - Fokus-5 - Medical Institution for Outpatient Care OOD
🇧🇬Sofia, Bulgaria
Dermatology Research Institute Incorporated
🇨🇦Calgary, Alberta, Canada
Laser Rejuvenation Clinics Edmonton D T Incorporated
🇨🇦Edmonton, Alberta, Canada
Alberta Derma Surgery Centre
🇨🇦Edmonton, Alberta, Canada
Enverus Medical Research
🇨🇦Surrey, British Columbia, Canada
Wiseman Dermatology Research Incorporated
🇨🇦Winnipeg, Manitoba, Canada
SKiN Health
🇨🇦Coburg, Ontario, Canada
Centricity Research London
🇨🇦London, Ontario, Canada
Dr SK Siddha Medicine Professional Corporation
🇨🇦Newmarket, Ontario, Canada
Allergy Research Canada Incorporated
🇨🇦Niagara Falls, Ontario, Canada
North Bay Dermatology Centre
🇨🇦North Bay, Ontario, Canada
Dermatology Ottawa Research Centre
🇨🇦Ottawa, Ontario, Canada
JRB Research Incorporated
🇨🇦Ottawa, Ontario, Canada
The Centre for Dermatology
🇨🇦Richmond Hill, Ontario, Canada
North York Research Incorporated
🇨🇦Toronto, Ontario, Canada
Toronto Research Centre Inc
🇨🇦Toronto, Ontario, Canada
Alliance Clinical Trials
🇨🇦Waterloo, Ontario, Canada
Clinique de Dermatologie Rosemont
🇨🇦Montreal, Quebec, Canada
Innovaderm Research Inc
🇨🇦Montreal, Quebec, Canada
Saskatoon Dermatology Centre
🇨🇦Saskatoon, Saskatchewan, Canada
DIEX Recherche Quebec
🇨🇦Quebec, Canada
Centre de Recherche Saint-Louis
🇨🇦Quebec, Canada
Beijing Friendship Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
Peking University Third Hospital
🇨🇳Beijing, Beijing, China
The First Affiliated Hospital of Fujian Medical University
🇨🇳Fuzhou, Fujian, China
The First Affiliated Hospital ,Sun-Yat Sen University
🇨🇳Guangzhou, Guangdong, China
Dermatology Hospital of Southern Medical University
🇨🇳Guangzhou, Guangdong, China
Sun Yat-sen Memorial Hospital Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
The Fist Affiliated Hospital of Shantou University Medical College
🇨🇳Shantou, Guangdong, China
Shenzhen Qianhai Shekou Free Trade Zone Hospital
🇨🇳Shenzhen, Guangdong, China
Nanyang First Peoples Hospital
🇨🇳Nanyang, Henan, China
Union Hospital Tongji Medical College Huazhong University of science and Technology
🇨🇳Wuhan, Hubei, China
Wuxi Second Peoples Hospital
🇨🇳Wuxi, Jiangsu, China
Dermatology Hospital of Jiangxi Province
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
Chengdu Second Peoples Hospital
🇨🇳Chengdu, Sichuan, China
the First Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Affiliated Hangzhou First Peoples Hospital，Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
The First Affiliation Hospital Of Ningbo University
🇨🇳Ningbo, Zhejiang, China
Taizhou Central Hospital
🇨🇳Taizhou, Zhejiang, China
Peking University Peoples Hospital
🇨🇳Beijing, China
Shanghai Skin Disease Hospital
🇨🇳Shanghai, China
Hopital Prive d Antony
🇫🇷Antony, France
Centre Hospitalier Universitaire de Bordeaux - Hôpital Saint André
🇫🇷Bordeaux, France
Centre Hospitalier Regional Universitaire Brest Hopital Morvan
🇫🇷Brest, France
Centre Hospitalier Régional Universitaire de Lille - Hôpital Claude Huriez
🇫🇷Lille, France
Centre Hospitalier de Bretagne Sud - Hopital du Scorff
🇫🇷Lorient Cedex, France
Hôpital La Timone
🇫🇷Marseille cedex 05, France
Cabinet du Docteur Ruer-Mulard Mireille
🇫🇷Martigues, France
Centre Hospitalier Universitaire de Nantes Hôtel Dieu
🇫🇷Nantes, France
Centre Hospitalier Universitaire Archet 2
🇫🇷Nice, France
Polyclinique de Courlancy
🇫🇷Reims, France
Hopital Saint Louis
🇫🇷Paris Cedex 10, France
Hopital Bichat Claude Bernard
🇫🇷Paris, France
Hopital Tenon
🇫🇷Paris, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
🇫🇷Rennes Cedex 9, France
Centre Hospitalier Universitaire de Rouen - Hôpital Charles Nicolle
🇫🇷Rouen Cedex, France
Centre Hospitalier Universitaire Saint Etienne Hopital Nord
🇫🇷Saint Priest en Jarez, France
Hopital d instruction des armees sainte anne
🇫🇷Toulon, France
Universitaetsklinikum Frankfurt
🇩🇪Frankfurt am Main, Germany
Universitaetsmedizin Goettingen - Georg-August-Universitaet
🇩🇪Goettingen, Germany
Hautaerzte Zentrum Hannover
🇩🇪Hannover, Germany
TFS Trial Form Support GmbH
🇩🇪Hamburg, Germany
MensingDerma research GmbH
🇩🇪Hamburg, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Universitaetsmedizin Mainz
🇩🇪Mainz, Germany
Beldio Research GmbH
🇩🇪Memmingen, Germany
Hautmedizin Saar
🇩🇪Merzing, Germany
Klinikum rechts der Isar der TUM
🇩🇪Muenchen, Germany
401 General Military Hospital Of Athens
🇬🇷Athens, Greece
University General Hospital of Heraklion
🇬🇷Heraklion, Greece
Andreas Syngros Hospital Of Venereal And Dermatological Diseases
🇬🇷Athens, Greece
General Hospital Of Nea Ionia Konstantopouleio Patision
🇬🇷Nea Ionia, Greece
Geniko Nosokomeio Peiraia Tzaneio
🇬🇷Piraeus, Greece
Ippokratio General Hospital of Thessaloniki
🇬🇷Thessaloniki, Greece
Trial Pharma Kft
🇭🇺Bekescsaba, Hungary
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
🇮🇹Roma, Italy
IRCCS Istituto Clinico Humanitas
🇮🇹Rozzano MI, Italy
Fukui Dermatology Clinic
🇯🇵Nagoya-shi, Aichi, Japan
Ekihigashi Dermatology Allergy Clinic
🇯🇵Fukuoka-shi, Fukuoka, Japan
Takagi Dermatological Clinic Branch
🇯🇵Obihiro-shi, Hokkaido, Japan
Medical Corporation Kojinkai Sapporo Skin Clinic
🇯🇵Sapporo-shi, Hokkaido, Japan
Katahira Dermatology Urology Clinic
🇯🇵Kagoshima-shi, Kagoshima, Japan
Jouzan Hihuka Hinyoukika Clinic
🇯🇵Kumamoto-shi, Kumamoto, Japan
Kosugi Dermatology Clinic
🇯🇵Kawasaki-shi, Kanagawa, Japan
Nomura Dermatology Clinic
🇯🇵Yokohama-shi, Kanagawa, Japan
Suizenji Dermatology Clinic
🇯🇵Kumamoto-shi, Kumamoto, Japan
Yoshioka Dermatology Clinic
🇯🇵Neyagawa-shi, Osaka, Japan
JA Shizuoka Kohseiren Enshu Hospital
🇯🇵Hamamatsu-shi, Shizuoka, Japan
Mildix Skin Clinic
🇯🇵Adachi-ku, Tokyo, Japan
Naoko Dermatology Clinic
🇯🇵Setagaya-ku, Tokyo, Japan
NTT Medical Center Tokyo
🇯🇵Shinagawa-ku, Tokyo, Japan
Yamate Dermatology Clinic
🇯🇵Shinjuku-ku, Tokyo, Japan
Hospital Sultan Ismail
🇲🇾Johor Bahru, Johor, Malaysia
Hospital Raja Permaisuri Bainun
🇲🇾Ipoh, Perak, Malaysia
Hospital Kuala Lumpur
🇲🇾Kuala Lumpur, Wilayah Persekutuan, Malaysia
Hospital Pulau Pinang
🇲🇾Georgetown, Pinang, Malaysia
Queen Elizabeth Hospital
🇲🇾Kota Kinabalu, Sabah, Malaysia
Pusat Perubatan Universiti Kebangsaan Malaysia
🇲🇾Kuala Lumpur, Wilayah Persekutuan, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Wilayah Persekutuan, Malaysia
Bravis Ziekenhuis
🇳🇱Bergen op Zoom, Netherlands
Universitair Medisch Centrum Groningen
🇳🇱Groningen, Netherlands
Universitair Medisch Centrum Utrecht
🇳🇱Utrecht, Netherlands
Dermapolis Medical Dermatology Center dr n med Edyta Gebska
🇵🇱Chorzow, Poland
GynCentrum Spzoo NZOZ Holsamed - Oddzial Libero
🇵🇱Katowice, Poland
Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski Pawel Brzewski SpCywilna
🇵🇱Krakow, Poland
AppleTreeClinics Network Spzoo
🇵🇱Lodz, Poland
Ip Clinic Sp zoo
🇵🇱Lodz, Poland
Twoja Przychodnia Scm
🇵🇱Szczecin, Poland
DermMedica Spzoo Centrum Columbus
🇵🇱Wroclaw, Poland
Doctor Samuel Sanchez PSC
🇵🇷Caguas, Puerto Rico
Theramed Healthcare SRL
🇷🇴Brasov, Romania
Institutul Regional de Gastroenterologie si Hepatologie Prof Dr Octavian Fodor
🇷🇴Cluj-Napoca, Romania
Spitalul Clinic Judetean Mures
🇷🇴Targu Mures, Romania
National University Hospital
🇸🇬Singapore, Singapore
Singapore General Hospital
🇸🇬Singapore, Singapore
National Skin Centre
🇸🇬Singapore, Singapore
Maxderm, sro
🇸🇰Bardejov, Slovakia
Univerzitna nemocnica Bratislava - Nemocnica Stare Mesto
🇸🇰Bratislava, Slovakia
Fakultna nemocnica s poliklinikou JA Reimana Presov
🇸🇰Presov, Slovakia
Sanare spol sro
🇸🇰Svidnik, Slovakia
Univerzitetni klinicni center Ljubljana
🇸🇮Ljubljana, Slovenia
Hospital Clinic i Provincial de Barcelona
🇪🇸Barcelona, Cataluña, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Comunidad Valenciana, Spain
Hospital Universitario Basurto
🇪🇸Bilbao, País Vasco, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Complexo Hospitalario Universitario de Pontevedra
🇪🇸Pontevedra, Spain
Inselspital Bern
🇨🇭Bern, Switzerland
Hopitaux Universitaires de Geneve
🇨🇭Geneve 14, Switzerland
Centre Hospitalier Universitaire Vaudois
🇨🇭Lausanne, Switzerland
Kantonsspital Sankt Gallen
🇨🇭Sankt Gallen, Switzerland
Universitaetsspital Zuerich
🇨🇭Zuerich, Switzerland
Ankara Bilkent Sehir Hastanesi
🇹🇷Ankara, Turkey
Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi
🇹🇷Istanbul, Turkey
Acibadem Altunizade Hastanesi
🇹🇷Istanbul, Turkey
Marmara Universitesi Tip Fakultesi Hastanesi
🇹🇷Istanbul, Turkey
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
🇹🇷Samsun, Turkey
Royal United Hospitals Bath NHS Foundation Trust
🇬🇧Bath, United Kingdom
Russells Hall Hospital
🇬🇧Dudley, United Kingdom
West Middlesex University Hospital
🇬🇧Isleworth, United Kingdom
The Royal Free Hospital
🇬🇧London, United Kingdom
Accellacare Yorkshire
🇬🇧Shipley, United Kingdom